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ZNRF2 Knockout Cell Lines

Gene: ZNRF2

Official Full Name: zinc and ring finger 2provided by HGNC

Gene Summary: Enables ubiquitin protein ligase activity. Involved in positive regulation of autophagosome-lysosome fusion. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. Is active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26804 ZNRF2 Knockout cell line (HeLa) Human ZNRF2 1:3~1:6 Negative Online Inquiry
KO26805 ZNRF2 Knockout cell line (HCT 116) Human ZNRF2 1:2~1:4 Negative Online Inquiry
KO26806 ZNRF2 Knockout cell line (HEK293) Human ZNRF2 1:3~1:6 Negative Online Inquiry
KO26807 ZNRF2 Knockout cell line (A549) Human ZNRF2 1:3~1:4 Negative Online Inquiry

Background

ZNRF2 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to disrupt the expression of the ZNRF2 gene, which encodes a protein associated with cellular and signaling processes, particularly in the context of cell proliferation and differentiation. By utilizing CRISPR-Cas9 technology, these knockout cell lines serve as a powerful tool for researchers aiming to elucidate the functional role of ZNRF2 in various biological pathways and disease states.

The key mechanisms behind the ZNRF2 knockout involve the targeted deletion of exons within the gene, resulting in frameshift mutations that hinder protein synthesis. This alteration allows scientists to observe the phenotypic consequences of ZNRF2 loss, which is crucial for understanding its role in cancer biology, immunological responses, and developmental processes. By studying these knockout cell lines, researchers can track changes in cellular behavior, signaling cascades, and gene expression profiles, leading to insights into the therapeutic potential of targeting ZNRF2.

In clinical and research settings, ZNRF2 Gene Knockout Cell Lines are invaluable for drug discovery, biomarker identification, and the development of targeted therapies. Their application extends to various fields, including oncology, cardiovascular research, and regenerative medicine, as they facilitate the identification of new therapeutic strategies aimed at modulating ZNRF2-related pathways.

A significant advantage of these knockout cell lines over traditional models is their precise gene targeting, reducing the likelihood of off-target effects and enabling reproducible results. Unlike other genetic modification techniques, the CRISPR-Cas9 approach allows for rapid generation and easy maintenance of the knockout phenotype, making experimentation more efficient.

For researchers and clinicians looking to deepen their understanding of gene function and its implications in disease, ZNRF2 Gene Knockout Cell Lines represent a critical resource. Our company prides itself on its commitment to providing high-quality biological products, backed by extensive expertise in gene editing technologies. With our advanced offerings, we empower the scientific community to explore groundbreaking research opportunities and foster significant advancements in health and disease management.

Please note that all services are for research use only. Not intended for any clinical use.

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