Gene: ZNF546
Official Full Name: zinc finger protein 546provided by HGNC
Gene Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12177 | ZNF546 Knockout cell line (HeLa) | Human | ZNF546 | 1:3~1:6 | Negative | Online Inquiry |
KO12178 | ZNF546 Knockout cell line (HEK293) | Human | ZNF546 | 1:3~1:6 | Negative | Online Inquiry |
KO12179 | ZNF546 Knockout cell line (A549) | Human | ZNF546 | 1:3~1:4 | Negative | Online Inquiry |
ZNF546 Gene Knockout Cell Lines are specifically engineered cellular models in which the ZNF546 gene has been disrupted, enabling researchers to study the gene's functions and implications in various biological processes. ZNF546 encodes a zinc finger protein that plays a significant role in transcriptional regulation and chromatin remodeling, influencing gene expression and cellular responses. The knockout of this gene allows for the elucidation of its role in cellular pathways and disease states, particularly those related to cancer and neurological disorders.
The primary mechanism of action in ZNF546 knockout cell lines involves the loss of function of the ZNF546 protein, which can lead to alterations in gene expression profiles and metabolic pathways within the cells. Through the use of CRISPR/Cas9 technology or similar gene-editing techniques, these cell lines provide a precise platform to explore the molecular dynamics associated with ZNF546, facilitating investigations into its impact on cellular differentiation, proliferation, and apoptosis.
The scientific significance of ZNF546 knockout cell lines extends to both basic research and clinical applications. They serve as invaluable tools for understanding the underlying mechanisms of disease, providing insights that can guide therapeutic strategies. Additionally, their relevance in pharmacogenomics makes them critical in drug development and testing, helping to identify potential targets and predict responses to treatments.
Compared to conventional wild-type cell lines, ZNF546 knockout variants present unique advantages, such as increased specificity in assessing gene function while minimizing off-target effects. This targeted approach enhances the reliability of experimental results, offering researchers more conclusive data to support their hypotheses.
For researchers and clinicians dedicated to advancing the field of molecular biology and therapeutic interventions, ZNF546 Gene Knockout Cell Lines represent a significant resource. They offer a streamlined avenue to unravel complex genetic interactions and contribute to the development of novel treatment modalities.
As a leader in genetic engineering technologies, our company is committed to providing high-quality, reliable products designed for cutting-edge research. Our expertise in creating specialized cell lines ensures that you are equipped with the tools needed to drive discovery and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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