Gene: ZNF488
Official Full Name: zinc finger protein 488provided by HGNC
Gene Summary: Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in oligodendrocyte development and regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of oligodendrocyte differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30403 | ZNF488 Knockout cell line (HeLa) | Human | ZNF488 | 1:3~1:6 | Negative | Online Inquiry |
KO30404 | ZNF488 Knockout cell line (HCT 116) | Human | ZNF488 | 1:2~1:4 | Negative | Online Inquiry |
KO30405 | ZNF488 Knockout cell line (HEK293) | Human | ZNF488 | 1:3~1:6 | Negative | Online Inquiry |
KO30406 | ZNF488 Knockout cell line (A549) | Human | ZNF488 | 1:3~1:4 | Negative | Online Inquiry |
ZNF488 Gene Knockout Cell Lines are an advanced biotechnological tool designed to facilitate in-depth studies of the ZNF488 gene's function in cellular processes. ZNF488, a member of the zinc finger protein family, is implicated in various biological processes, including gene expression modulation, cellular differentiation, and responses to environmental stimuli. The knockout cell lines utilize CRISPR-Cas9 genome-editing technology to reliably disrupt the ZNF488 gene, enabling researchers to analyze the resultant phenotypic changes and delineate the gene’s role in both normal and pathological contexts.
These cell lines operate on a principle of targeted mutagenesis, wherein a specific guide RNA (gRNA) directs the Cas9 nuclease to create a double-strand break at the ZNF488 locus. Cellular repair mechanisms then introduce modifications that effectively knockout gene expression. This precision allows for detailed investigations into downstream effects, revealing insights into how ZNF488 influences critical cellular pathways and contributing to a better understanding of diseases such as cancer and developmental disorders.
The scientific importance of ZNF488 Gene Knockout Cell Lines lies in their application in both basic research and translational medicine. Researchers can utilize these models to dissect gene function, pathway interactions, and even explore therapeutic interventions by creating new hypotheses regarding target genes. Furthermore, utilizing these cell lines in drug screening processes can lead to the identification of novel therapeutic targets.
What sets ZNF488 Gene Knockout Cell Lines apart from traditional knockout models is their enhanced specificity and efficiency, coupled with the ease of use that CRISPR technology affords. Compared to earlier approaches, these cell lines provide a more streamlined workflow, allowing for rapid generation and validation of knockout variants without the complexities associated with homologous recombination.
Ultimately, ZNF488 Gene Knockout Cell Lines represent a crucial resource for researchers and clinicians aiming to unlock the intricacies of gene function in a controlled environment. By leveraging our expertise in molecular biology and gene editing, our company ensures that these products are not only of the highest quality but also supported by a commitment to advancing scientific understanding and innovation in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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