Gene: ZNF484
Official Full Name: zinc finger protein 484provided by HGNC
Gene Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25381 | ZNF484 Knockout cell line (HeLa) | Human | ZNF484 | 1:3~1:6 | Negative | Online Inquiry |
KO25382 | ZNF484 Knockout cell line (HCT 116) | Human | ZNF484 | 1:2~1:4 | Negative | Online Inquiry |
KO25383 | ZNF484 Knockout cell line (HEK293) | Human | ZNF484 | 1:3~1:6 | Negative | Online Inquiry |
KO25384 | ZNF484 Knockout cell line (A549) | Human | ZNF484 | 1:3~1:4 | Negative | Online Inquiry |
ZNF484 Gene Knockout Cell Lines are genetically modified cell lines in which the ZNF484 gene has been specifically disrupted using CRISPR/Cas9 technology. This innovative approach allows for precise alterations in the genome to study the gene's function and its implications in various biological processes. By completely knocking out the ZNF484 gene, these cell lines serve as essential tools for understanding gene regulatory networks and their roles in cellular behavior.
The primary function of ZNF484 involves its regulation of gene expression associated with various developmental and disease processes. The knockout mechanism primarily relies on the Cas9 nuclease, which introduces double-strand breaks in the DNA at specific ZNF484 loci, leading to insertions or deletions that render the gene inoperative. This technique not only provides insights into the signaling pathways modulated by ZNF484 but also enables researchers to investigate the consequences of its absence on cellular functions such as proliferation, differentiation, and apoptosis.
The scientific importance of these knockout cell lines lies in their applications across multiple research domains, including cancer biology, neurodevelopment, and genetic disorders. By elucidating the biological pathways impacted by ZNF484, researchers can contribute to novel therapeutic approaches, biomarker discovery, and personalized medicine strategies. Moreover, such models can be employed in drug screening assays, thereby bridging the gap between bench research and clinical advancements.
Compared to alternative methods for gene modification, ZNF484 Gene Knockout Cell Lines offer superior specificity and efficiency. Traditional methods, such as RNA interference or transgenic approaches, often lack the rigor and precision of CRISPR/Cas9 knockouts. Furthermore, these cell lines are generated in a standardized format, allowing for reproducible results across experiments, thus enhancing their reliability for researchers.
The value of ZNF484 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated. They provide an unparalleled opportunity to dissect gene functions and their relationships to pathophysiological conditions, ultimately paving the way for groundbreaking discoveries. Employing these specialized tools will enable users to stay at the forefront of genetic research and improve their understanding of complex biological systems.
Our company is committed to supporting cutting-edge scientific research through the provision of high-quality biological products, including this innovative ZNF484 Gene Knockout Cell Line. With extensive experience in gene editing technologies, we stand as a trusted partner in advancing your research objectives.
Please note that all services are for research use only. Not intended for any clinical use.
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