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ZNF195 Knockout Cell Lines

Gene: ZNF195

Official Full Name: zinc finger protein 195provided by HGNC

Gene Summary: This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34525 ZNF195 Knockout cell line (HeLa) Human ZNF195 1:3~1:6 Negative Online Inquiry
KO34526 ZNF195 Knockout cell line (HCT 116) Human ZNF195 1:2~1:4 Negative Online Inquiry
KO34527 ZNF195 Knockout cell line (HEK293) Human ZNF195 1:3~1:6 Negative Online Inquiry
KO34528 ZNF195 Knockout cell line (A549) Human ZNF195 1:3~1:4 Negative Online Inquiry

Background

ZNF195 Gene Knockout Cell Lines are specialized cellular models that have been engineered to contain a disruptive mutation in the ZNF195 gene, a member of the zinc finger protein family involved in various biological processes including transcriptional regulation and genomic integrity. These knockout cell lines serve as an invaluable tool for researchers aiming to elucidate the role of ZNF195 in a myriad of cellular functions, including cell growth, differentiation, and stress response mechanisms.

The primary function of these knockout cell lines is to provide a platform where the absence of ZNF195 can be observed. This enables scientists to study the downstream effects of its loss on cellular pathways and phenotypic expressions, by utilizing techniques such as gene expression analysis, protein interaction studies, and functional assays. By silencing the ZNF195 gene, researchers can gain insights into its potential contributions to conditions such as cancer and other genetic disorders, thereby advancing our understanding of these diseases at the molecular level.

The scientific importance of ZNF195 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, these models can facilitate the identification of novel therapeutic targets, offering opportunities to develop interventions aimed at correcting the downstream effects of ZNF195 malfunction. Additionally, they can serve as a model system to assess the efficacy of drugs designed to modulate the activities of related pathways.

Compared to alternative cell lines that might retain functional ZNF195, these knockout variants present a definitive advantage: they allow for the isolation of specific perturbations directly attributable to the loss of ZNF195. This early-stage model prevents the confounding factors often associated with partial or functional gene presence that can skew experimental outcomes and interpretations.

For researchers and clinicians alike, ZNF195 Gene Knockout Cell Lines represent a key resource that streamlines the study of this gene's role in health and disease. Their ability to reflect the biological realities of ZNF195 deficiency provides a robust framework for discovery and innovation. Our company specializes in producing high-quality, validated knockout cell lines, ensuring that researchers have access to reliable tools that support their scientific inquiries.

Please note that all services are for research use only. Not intended for any clinical use.

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