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ZFAT Knockout Cell Lines

Gene: ZFAT

Official Full Name: zinc finger and AT-hook domain containingprovided by HGNC

Gene Summary: This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20433 ZFAT Knockout cell line (HeLa) Human ZFAT 1:3~1:6 Negative Online Inquiry
KO20434 ZFAT Knockout cell line (HCT 116) Human ZFAT 1:2~1:4 Negative Online Inquiry
KO20435 ZFAT Knockout cell line (HEK293) Human ZFAT 1:3~1:6 Negative Online Inquiry
KO20436 ZFAT Knockout cell line (A549) Human ZFAT 1:3~1:4 Negative Online Inquiry

Background

ZFAT Gene Knockout Cell Lines are innovative biological tools designed to facilitate the study of ZFAT (Zinc Finger AT-Hook Domain Containing) gene function and its role in various biological processes. By utilizing CRISPR-Cas9 technology, these cell lines have been engineered to have a complete deletion of the ZFAT gene, allowing researchers to investigate the resultant phenotypic changes, signaling pathways, and cellular mechanisms that occur in its absence.

The primary function of ZFAT is to regulate gene expression by acting as a transcriptional co-activator in processes such as cell proliferation, differentiation, and immune response. The knockout of ZFAT significantly alters cellular behavior, making these cell lines invaluable for dissecting the gene's contributions to pathophysiological conditions, particularly in cancer biology and autoimmune diseases. Researchers can utilize these cell models to conduct functional assays, elucidate molecular pathways, and evaluate therapeutic responses in a controlled environment.

The scientific importance of ZFAT Gene Knockout Cell Lines lies in their application in both fundamental research and potential clinical settings. They offer a platform for developing targeted therapies by identifying novel drug targets or understanding genetic factors influencing treatment efficacy. Compared to traditional knockout models, the precision of CRISPR-Cas9 technology ensures a clean genomic edit, reducing off-target effects and increasing the reliability of experimental outcomes.

What sets ZFAT Gene Knockout Cell Lines apart from alternative models is the specificity with which they have been engineered, enabling precise control over the experimental conditions. This specificity helps streamline research timelines and enhances reproducibility, leading to faster translation of discoveries to clinical applications.

For researchers and clinicians, ZFAT Gene Knockout Cell Lines represent an essential asset for exploring the intricacies of gene function and uncovering new therapeutic avenues. Furthermore, our company prides itself on its commitment to rigorous scientific innovation and quality assurance, consistently delivering advanced biological products that empower the research community and support groundbreaking discoveries in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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