Gene: ZBTB2
Official Full Name: zinc finger and BTB domain containing 2provided by HGNC
Gene Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12502 | ZBTB2 Knockout cell line (HeLa) | Human | ZBTB2 | 1:3~1:6 | Negative | Online Inquiry |
KO12503 | ZBTB2 Knockout cell line (HCT 116) | Human | ZBTB2 | 1:2~1:4 | Negative | Online Inquiry |
KO12504 | ZBTB2 Knockout cell line (HEK293) | Human | ZBTB2 | 1:3~1:6 | Negative | Online Inquiry |
KO12505 | ZBTB2 Knockout cell line (A549) | Human | ZBTB2 | 1:3~1:4 | Negative | Online Inquiry |
ZBTB2 Gene Knockout Cell Lines are genetically engineered cells designed to lack the functional ZBTB2 protein, a transcription factor that plays a pivotal role in regulating gene expression associated with various cellular processes, including differentiation, proliferation, and immune responses. These cell lines serve as an invaluable tool for researchers aiming to elucidate the biological functions of ZBTB2 and its involvement in pathological conditions such as cancer and autoimmune diseases.
The primary mechanism through which these knockout cell lines operate involves the disruption of the ZBTB2 gene, providing a unique model for studying gene function post-disruption. By examining these cells, researchers gain insights into how the absence of ZBTB2 alters cellular signaling pathways, gene regulation, and ultimately, cell behavior. This makes ZBTB2 gene knockout cell lines particularly useful in basic research, drug development, and therapeutic investigations.
Scientifically, the importance of ZBTB2 gene knockout cell lines cannot be overstated. They facilitate the exploration of ZBTB2's role in immune modulation and its potential as a therapeutic target in oncology. Additionally, they contribute to the understanding of gene regulatory networks, paving the way for innovative precision medicine approaches.
Compared to alternative models such as transient knockdown via siRNA or CRISPR/Cas9 interventions that may lead to transient or off-target effects, ZBTB2 knockout cell lines provide a stable and consistent platform for long-term studies. Their robust nature ensures reproducibility in experiments, lending credence to research findings.
For researchers and clinicians, the value of ZBTB2 Gene Knockout Cell Lines lies in their ability to provide definitive insights into gene function and therapeutic targeting. With our commitment to quality and innovation, our company leverages cutting-edge genetic engineering technologies to produce these cell lines, backed by extensive expertise in cellular biology and molecular genetics. Incorporating ZBTB2 Gene Knockout Cell Lines into your research can propel your discoveries and aid in advancing medical science.
Please note that all services are for research use only. Not intended for any clinical use.
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