Gene: WWP1
Official Full Name: WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
Gene Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03736 | WWP1 Knockout cell line (HeLa) | Human | WWP1 | 1:3~1:6 | Negative | Online Inquiry |
KO03737 | WWP1 Knockout cell line (HCT 116) | Human | WWP1 | 1:2~1:4 | Negative | Online Inquiry |
KO03738 | WWP1 Knockout cell line (HEK293) | Human | WWP1 | 1:3~1:6 | Negative | Online Inquiry |
KO03739 | WWP1 Knockout cell line (A549) | Human | WWP1 | 1:3~1:4 | Negative | Online Inquiry |
WWP1 Gene Knockout Cell Lines consist of genetically modified mammalian cells in which the WWP1 gene has been systematically inactivated through the application of CRISPR-Cas9 technology. This innovative approach facilitates the study of the functional role of the WWP1 gene, which is known to be involved in various cellular processes, including ubiquitylation and signal transduction pathways. By creating knockout models, researchers can elucidate the precise biological effects resulting from the absence of WWP1, thereby advancing our understanding of its implication in pathological conditions such as cancer and neurological disorders.
The primary mechanism by which WWP1 Gene Knockout Cell Lines operate involves the targeted disruption of the WWP1 gene, leading to a complete cessation of protein expression. This allows researchers to analyze changes in gene expression profiles, cellular behavior, and interaction networks that can modulate various disease pathways. Consequently, these cell lines serve as invaluable tools for examining the role of WWP1 in cellular physiology and pathology in both basic and applied research contexts.
The scientific importance of WWP1 Gene Knockout Cell Lines cannot be overstated; they provide a platform for dissecting the molecular mechanisms involved in disease progression and for identifying potential therapeutic targets. In clinical settings, understanding the nuances of WWP1's role could open new avenues for intervention, particularly in targeted therapies for malignancies where WWP1 is implicated.
What sets WWP1 Gene Knockout Cell Lines apart from alternative models is their specificity, reproducibility, and the minimal off-target effects generated during the knockout process, thanks to our refined CRISPR design. Moreover, these cell lines are readily available and can be utilized by laboratories of various sizes, making cutting-edge research more accessible.
In sum, WWP1 Gene Knockout Cell Lines are indispensable for any researcher or clinician focusing on gene function and therapeutic applications, with the potential for significant contributions to the understanding of complex biological systems. Our company prides itself on delivering high-quality biological products supported by years of expertise and research innovation, empowering scientists to push the boundaries of discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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