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VPS33B Knockout Cell Lines

Gene: VPS33B

Official Full Name: VPS33B late endosome and lysosome associatedprovided by HGNC

Gene Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28150 VPS33B Knockout cell line (HeLa) Human VPS33B 1:3~1:6 Negative Online Inquiry
KO28151 VPS33B Knockout cell line (HCT 116) Human VPS33B 1:2~1:4 Negative Online Inquiry
KO28152 VPS33B Knockout cell line (HEK293) Human VPS33B 1:3~1:6 Negative Online Inquiry
KO28153 VPS33B Knockout cell line (A549) Human VPS33B 1:3~1:4 Negative Online Inquiry

Background

VPS33B Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the VPS33B gene, which encodes for a protein integral to intracellular transport processes, particularly in exocytosis and endocytosis. These cell lines serve as crucial tools for investigating the functional implications of VPS33B loss, allowing researchers to delve into mechanisms of disease related to this gene, such as developmental disorders and congenital syndromes associated with impaired vesicle trafficking.

The key function of these knockout cell lines lies in their ability to mimic physiological conditions where VPS33B is deficient. By eliminating this gene, researchers can study the resultant cellular effects, including alterations in protein secretion pathways, impaired organelle function, and changes in cellular signaling cascades. This model provides valuable insights into the molecular underpinnings of various pathologies and assists in identifying potential therapeutic targets.

In research and clinical settings, VPS33B Gene Knockout Cell Lines hold significant importance for understanding diseases like Familial Hemophagocytic Lymphohistiocytosis (FHLH) and its relation to the immune response. The insights gained from using these cell lines aid in the development of gene therapies and targeted pharmacological interventions, making them invaluable assets in translational research.

One of the primary advantages of VPS33B Gene Knockout Cell Lines is their specificity and high fidelity in mimicking VPS33B deficiency compared to knockdown methods, which may not entirely eliminate gene function. Additionally, these cell lines can be cultured and manipulated easily, fitting seamlessly into existing experimental workflows, enhancing their utility in various research applications.

For researchers and clinicians focused on vesicle-mediated transport diseases, the VPS33B Gene Knockout Cell Lines represent an essential resource. They empower the scientific community to advance their understanding of crucial biological processes, paving the way for innovative therapeutic strategies.

Our company specializes in providing high-quality biological products backed by rigorous research and development. With a commitment to excellence and innovation, we ensure that our offerings, including the VPS33B Gene Knockout Cell Lines, meet the highest standards of scientific rigor and applicability, enabling researchers to push the boundaries of discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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