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VPS16 Knockout Cell Lines

Gene: VPS16

Official Full Name: VPS16 core subunit of CORVET and HOPS complexesprovided by HGNC

Gene Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05206 VPS16 Knockout cell line (HeLa) Human VPS16 1:3~1:6 Negative Online Inquiry
KO05207 VPS16 Knockout cell line (HCT 116) Human VPS16 1:2~1:4 Negative Online Inquiry
KO05208 VPS16 Knockout cell line (HEK293) Human VPS16 1:3~1:6 Negative Online Inquiry
KO05209 VPS16 Knockout cell line (A549) Human VPS16 1:3~1:4 Negative Online Inquiry

Background

VPS16 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the role of the VPS16 gene, which is integral in cellular membrane trafficking and protein sorting processes. These cell lines are developed using CRISPR-Cas9 technology, ensuring precise gene editing that enables the complete knockout of the VPS16 gene, allowing researchers to delve into its functional ramifications on cellular behavior and disease mechanisms.

The key function of VPS16 is its involvement in the maturation of multivesicular bodies and the sorting of ubiquitinated proteins for degradation via the lysosomal pathway. By utilizing these knockout cell lines, researchers can elucidate the mechanisms underlying disorders linked to aberrant VPS16 function, such as neurodegenerative diseases and certain cancers. This research is critical, as it can ultimately lead to new therapeutic strategies targeting these pathways.

The scientific importance of VPS16 Gene Knockout Cell Lines extends to both basic research and clinical applications. In laboratory settings, they serve as valuable tools to study gene function and cellular responses in unregulated environments. In clinical contexts, understanding the VPS16 gene's pathway can highlight potential biomarkers for disease and influence the development of targeted therapies.

Our VPS16 Gene Knockout Cell Lines offer several advantages over existing models. They provide a robust and reproducible platform for RNA interference and gene function studies while minimizing off-target effects common in traditional gene editing methods. Additionally, their compatibility with high-throughput screening assays enhances their utility in large-scale experimental setups, enabling rapid and accurate data collection.

For researchers and clinicians aiming to advance their understanding of VPS16-related cellular processes, adopting these knockout cell lines is invaluable. They present an opportunity to uncover new insights that can inform the next generation of therapeutic interventions.

With an extensive background in genomics and a commitment to developing advanced biological products, our company stands at the forefront of delivering high-quality research tools, empowering scientists and clinicians to achieve groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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