Gene: VIPR1
Official Full Name: vasoactive intestinal peptide receptor 1provided by HGNC
Gene Summary: This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34821 | VIPR1 Knockout cell line (HeLa) | Human | VIPR1 | 1:3~1:6 | Negative | Online Inquiry |
KO34822 | VIPR1 Knockout cell line (HCT 116) | Human | VIPR1 | 1:2~1:4 | Negative | Online Inquiry |
KO34823 | VIPR1 Knockout cell line (HEK293) | Human | VIPR1 | 1:3~1:6 | Negative | Online Inquiry |
VIPR1 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology research, specifically designed to facilitate comprehensive studies of the vasoactive intestinal peptide receptor 1 (VIPR1) gene. These engineered cell lines are created using advanced CRISPR/Cas9 technology, ensuring precise disruption of the VIPR1 gene, which plays a crucial role in mediating the physiological effects of vasoactive intestinal peptide (VIP). By providing a model to study the absence of VIPR1 function, these knockout cell lines enable researchers to elucidate the gene's involvement in various biological processes, including neuroimmune responses and circadian rhythmicity.
The mechanisms of action of VIPR1 knockout cell lines center around the consequent alterations in cellular signaling cascades and downstream effects upon VIP stimulation. Researchers can investigate how the loss of VIPR1 expression affects cell proliferation, differentiation, and secretory functions, thereby providing insights into its role in pathophysiological conditions such as cancer, neurodegenerative disorders, and metabolic syndromes.
The scientific importance of these cell lines extends their application potential in both basic and translational research settings. They are invaluable for drug discovery efforts aiming to identify potential therapeutic compounds that target the VIPR1-mediated pathways and for understanding the receptor's role in human health and disease.
Advantages of VIPR1 Gene Knockout Cell Lines over traditional models include the use of precise gene-editing techniques that minimize off-target effects, allowing for more reliable experimental outcomes. Additionally, they provide a consistent and homogeneous background for experimental studies, enhancing reproducibility.
As such, these knockout cell lines are an indispensable resource for researchers and clinicians looking to dissect the functional significance of VIPR1 in complex biological systems. By utilizing our meticulously developed VIPR1 Gene Knockout Cell Lines, users can accelerate their discovery processes, ultimately paving the way for novel therapeutic strategies targeting VIP-related pathways.
Our company specializes in providing high-quality genetic tools and resources for researchers in the field of molecular biology, leveraging our expertise to ensure that our products meet the stringent requirements of modern scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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