Gene: VEGFB
Official Full Name: vascular endothelial growth factor Bprovided by HGNC
Gene Summary: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09921 | VEGFB Knockout cell line (HeLa) | Human | VEGFB | 1:3~1:6 | Negative | Online Inquiry |
KO09922 | VEGFB Knockout cell line (HCT 116) | Human | VEGFB | 1:2~1:4 | Negative | Online Inquiry |
KO09923 | VEGFB Knockout cell line (HEK293) | Human | VEGFB | 1:3~1:6 | Negative | Online Inquiry |
KO09924 | VEGFB Knockout cell line (A549) | Human | VEGFB | 1:3~1:4 | Negative | Online Inquiry |
VEGFB Gene Knockout Cell Lines represent a pivotal resource in the fields of molecular biology and cancer research, designed specifically to facilitate the study of vascular endothelial growth factor B (VEGFB) and its associated pathways. These cell lines have been genetically engineered to lack the VEGFB gene, allowing researchers to investigate the biological effects resulting from the absence of this key regulator of angiogenesis and lymphangiogenesis.
The primary function of these knockout cell lines lies in their ability to serve as powerful tools for elucidating the role of VEGFB in physiological processes and disease states. By providing a controlled environment where VEGFB expression is absent, researchers can dissect signaling pathways, identify downstream targets, and assess the impact on cellular behaviors such as proliferation, migration, and apoptosis. This targeted analysis is critical for understanding the complexities of tumor microenvironments and the interplay of growth factors.
Scientifically, VEGFB is crucial for studies related to vascular diseases, cancer metastasis, and ischemia. The knockout cell lines enable researchers to explore alternative therapeutic strategies targeting VEGF pathways without the confounding influence of VEGFB. In clinical settings, the findings derived from these studies could potentially guide the development of novel treatment protocols aimed at improving patient outcomes in diseases characterized by aberrant angiogenesis.
The unique selling points of our VEGFB Gene Knockout Cell Lines include their high reliability and reproducibility in experimentation, which enhance the validity of research outcomes. Unlike alternative products, these cell lines are rigorously validated, ensuring the fidelity of results stemming from experiments that utilize them. Researchers will find that these knockout models provide an unprecedented opportunity to investigate VEGFB’s role in a range of biological contexts, thereby accelerating discovery and innovation.
Investing in our VEGFB Gene Knockout Cell Lines will not only advance your research capabilities but also provide a deeper understanding of complex biological systems, which is invaluable for driving forward both basic and translational science. At [Your Company], we pride ourselves on our commitment to quality and innovation in biological products, empowering scientists and clinicians with the tools necessary to unlock breakthroughs in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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