Gene: VASH2
Official Full Name: vasohibin 2provided by HGNC
Gene Summary: Enables actin binding activity; metallocarboxypeptidase activity; and microtubule binding activity. Involved in axon development and proteolysis. Acts upstream of or within cell-cell fusion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12698 | VASH2 Knockout cell line (HeLa) | Human | VASH2 | 1:3~1:6 | Negative | Online Inquiry |
KO12699 | VASH2 Knockout cell line (HCT 116) | Human | VASH2 | 1:2~1:4 | Negative | Online Inquiry |
KO12700 | VASH2 Knockout cell line (HEK293) | Human | VASH2 | 1:3~1:6 | Negative | Online Inquiry |
KO12701 | VASH2 Knockout cell line (A549) | Human | VASH2 | 1:3~1:4 | Negative | Online Inquiry |
VASH2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the functional role of the VASH2 gene, which encodes a key protein involved in vascular and cellular processes. By employing advanced CRISPR-Cas9 technology, these knockout lines exhibit a precise disruption of the VASH2 gene, allowing researchers to investigate the gene's biological functions and associated pathways. This can unveil critical insights into mechanisms governing angiogenesis, cell survival, and tissue regeneration.
The primary mechanism of action for VASH2 is its participation in the regulation of angiogenic factors and modulation of endothelial cell behavior. By creating the VASH2 knockout model, researchers can observe phenotypic changes, metabolic alterations, and gene expression profiles that arise in the absence of VASH2, offering a clearer understanding of its role in various physiological and pathological contexts, such as cancer metastasis and cardiovascular diseases.
The scientific importance of VASH2 knockout cell lines extends to both basic and translational research, facilitating studies in drug development, disease modeling, and therapeutics aimed at diseases characterized by aberrant angiogenesis. In clinical contexts, these cell lines can assist in identifying novel therapeutic targets or biomarkers, potentially advancing personalized medicine approaches for conditions influenced by VASH2 activity.
One of the significant advantages of our VASH2 Gene Knockout Cell Lines is their ready-to-use status, which accelerates the research timeline by eliminating the need for labor-intensive gene-editing processes. Compared to traditional transgenic models, these knockout lines offer a more straightforward and reproducible methodology for scientists. Furthermore, they come with comprehensive support documentation and protocols to enhance experimental success rates.
For researchers and clinicians, the value of using VASH2 Gene Knockout Cell Lines lies in their potential to provide critical insights into gene function and its implications in disease mechanisms. With the power to eliminate confounding genetic variables, these cell lines offer a stable platform for hypothesis-driven research.
At our company, we pride ourselves on our extensive experience in genetic engineering and our commitment to providing high-quality biological tools for the research community. By continuously expanding our portfolio of knockout models and supporting resources, we aim to empower scientists in their quest for discovery and innovation in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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