Gene: USP35
Official Full Name: ubiquitin specific peptidase 35provided by HGNC
Gene Summary: This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12737 | USP35 Knockout cell line (HeLa) | Human | USP35 | 1:3~1:6 | Negative | Online Inquiry |
KO12738 | USP35 Knockout cell line (HCT 116) | Human | USP35 | 1:2~1:4 | Negative | Online Inquiry |
KO12739 | USP35 Knockout cell line (HEK293) | Human | USP35 | 1:3~1:6 | Negative | Online Inquiry |
KO12740 | USP35 Knockout cell line (A549) | Human | USP35 | 1:3~1:4 | Negative | Online Inquiry |
USP35 Gene Knockout Cell Lines are specialized cellular models engineered to lack the functional USP35 gene, which encodes a ubiquitin-specific protease involved in various biological processes, including protein homeostasis and cellular signaling pathways. By eliminating this gene, the cell lines allow researchers to examine the role of USP35 in essential biological mechanisms such as gene regulation, apoptosis, and immune response, thereby providing a clearer understanding of its contributions to both normal physiology and disease pathology.
These cell lines operate through the mechanism of targeted genetic modification, typically employing CRISPR-Cas9 technology to induce specific deletions in the USP35 gene. This precision facilitates investigations into the downstream effects of USP35 loss, enabling researchers to delve into the underlying molecular changes that may lead to disease states, including cancer and chronic inflammatory conditions. This makes the USP35 Gene Knockout Cell Lines particularly valuable in toxicology studies and drug development, as they provide a robust model for assessing therapeutic efficacy and safety in the context of USP35's biological roles.
The scientific importance of these cell lines extends to their application in both basic and translational research. By providing a platform to explore the functional implications of USP35 loss, researchers can develop targeted therapies and biomarkers pertinent to diseases where USP35 plays a critical role. Compared to other knockout models, USP35 Gene Knockout Cell Lines are explicitly tailored to address queries surrounding the ubiquitin-proteasome system, offering unique insights that can lead to novel approaches in managing various ailments.
The advantages of utilizing USP35 Gene Knockout Cell Lines include their ability to replicate human disease conditions more accurately, thus translating findings more effectively into clinical settings. Furthermore, they help circumvent some of the limitations associated with traditional animal models, such as ethical concerns and interspecies variability.
Incorporating this product into your research not only enhances experimental rigor but also accelerates discovery in molecular biology and medicine. Our company, a leader in the production of high-quality biological models, stands behind the reliability and innovation of the USP35 Gene Knockout Cell Lines, ensuring that researchers and clinicians have the tools necessary to advance our understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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