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USP33 Knockout Cell Lines

Gene: USP33

Official Full Name: ubiquitin specific peptidase 33provided by HGNC

Gene Summary: This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05924 USP33 Knockout cell line (HeLa) Human USP33 1:3~1:6 Negative Online Inquiry
KO05925 USP33 Knockout cell line (HCT 116) Human USP33 1:2~1:4 Negative Online Inquiry
KO05926 USP33 Knockout cell line (HEK293) Human USP33 1:3~1:6 Negative Online Inquiry
KO05927 USP33 Knockout cell line (A549) Human USP33 1:3~1:4 Negative Online Inquiry

Background

USP33 Gene Knockout Cell Lines are genetically engineered cell lines in which the USP33 gene has been deliberately disrupted using advanced CRISPR/Cas9 gene-editing technology. This product allows researchers to study the function of USP33 and its role in various biological processes, including cell signaling, differentiation, and disease progression. By knocking out the USP33 gene, these cell lines provide a unique model system for investigating the molecular mechanisms associated with cellular homeostasis and stress responses.

The USP33 gene is known to encode an important deubiquitinating enzyme that regulates protein stability and signaling pathways by removing ubiquitin moieties from target proteins. By utilizing these knockout cell lines, researchers can examine the effects of USP33 loss on cellular functions, gene expression profiles, and the response to external stimuli such as drug treatments or environmental stressors. This makes them invaluable in elucidating the role of USP33 in oncogenesis, inflammation, and other critical pathological conditions.

In contrast to traditional methods of gene silencing, such as siRNA, our USP33 Gene Knockout Cell Lines offer a permanent genetic modification, leading to stable and reproducible results. Additionally, they allow for the assessment of both phenotypic and functional changes in a controlled manner. The ability to conduct long-term studies on cellular behavior significantly enhances the understanding of USP33's role in biological contexts.

The scientific community continues to expand its understanding of deubiquitinating enzymes, making our USP33 Gene Knockout Cell Lines crucial tools for both academic research and pharmaceutical development. Researchers and clinicians will find these cell lines particularly valuable in drug discovery and mechanism validation, where understanding the nuances of kinase and substrate interactions is essential.

At our company, we pride ourselves on harnessing cutting-edge gene-editing technologies to facilitate biological research. Our expertise in providing high-quality knockout cell lines ensures that researchers can rely on our products to advance their studies in a competitive landscape. By choosing our USP33 Gene Knockout Cell Lines, you invest in unparalleled quality and innovation, propelling your research towards meaningful breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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