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USP20 Knockout Cell Lines

Gene: USP20

Official Full Name: ubiquitin specific peptidase 20provided by HGNC

Gene Summary: This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00005 USP20 Knockout cell line (THP-1) Human USP20 1:2-1:4 Negative Online Inquiry
KO05798 USP20 Knockout cell line (HeLa) Human USP20 1:3~1:6 Negative Online Inquiry
KO05799 USP20 Knockout cell line (HCT 116) Human USP20 1:2~1:4 Negative Online Inquiry
KO05800 USP20 Knockout cell line (HEK293) Human USP20 1:3~1:6 Negative Online Inquiry
KO05801 USP20 Knockout cell line (A549) Human USP20 1:3~1:4 Negative Online Inquiry

Background

USP20 Gene Knockout Cell Lines consist of genetically modified cell lines in which the USP20 gene, a pivotal component in cellular regulatory pathways, has been systematically inactivated. This innovative product facilitates the study of the biological role of USP20, which encodes a deubiquitinating enzyme involved in modulating various cellular processes such as protein stability, intracellular signaling, and immune responses.

Key functions of USP20 Gene Knockout Cell Lines revolve around their ability to elucidate the effects of USP20 loss on cellular dynamics and pathways, providing researchers with a powerful tool for investigating the enzyme's influence on the ubiquitin-proteasome system. By leveraging these cell lines, scientists can conduct a myriad of experiments that explore the functional implications of USP20 knockout, advancing our understanding of diseases associated with dysregulated ubiquitin pathways and potentially facilitating drug discovery and development.

The scientific importance of these cell lines is particularly pronounced in translational research settings, where the proper functioning of the ubiquitin-proteasome system is critical in the context of cancer, neurodegenerative conditions, and immunological disorders. Hence, applications extend from basic research to potential therapeutic interventions, making USP20 Gene Knockout Cell Lines invaluable for both researchers and clinicians aiming to decode the complexities of protein regulation.

Compared to alternative cell models, USP20 Gene Knockout Cell Lines are designed with high specificity and reproducibility, minimizing off-target effects and maximizing experimental integrity. Their optimized use in high-throughput screening platforms sets them apart, enabling researchers to efficiently evaluate pharmacological candidates in a genetically controlled environment.

The value of USP20 Gene Knockout Cell Lines lies in their unique ability to provide robust data and insights into the role of deubiquitinating enzymes, which are often overlooked in traditional studies. By choosing our product, researchers and clinicians are equipped with a precise tool that enhances experimental outcomes and drives innovation in the understanding of complex cellular processes.

With our extensive expertise in cellular biology and genetic engineering, we are committed to providing high-quality biological products that empower researchers and contribute to advancements in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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