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USP19 Knockout Cell Lines

Gene: USP19

Official Full Name: ubiquitin specific peptidase 19provided by HGNC

Gene Summary: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31442 USP19 Knockout cell line (HeLa) Human USP19 1:3~1:6 Negative Online Inquiry
KO31443 USP19 Knockout cell line (HCT 116) Human USP19 1:2~1:4 Negative Online Inquiry
KO31444 USP19 Knockout cell line (HEK293) Human USP19 1:3~1:6 Negative Online Inquiry
KO31445 USP19 Knockout cell line (A549) Human USP19 1:3~1:4 Negative Online Inquiry

Background

USP19 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the expression of the USP19 gene, which is implicated in various cellular processes including protein degradation, cellular stress responses, and the regulation of immune functions. By creating a knockout model, researchers can study the specific contributions of USP19 in cellular pathways, enabling a deeper understanding of its role in both normal physiological conditions and disease states.

These cell lines utilize CRISPR-Cas9 technology for precise gene editing, ensuring a targeted ablation of USP19 without affecting surrounding genomic regions. The knockout mechanism permits the observation of phenotypic changes that arise from the absence of USP19, linking its function to key biological processes such as apoptosis, cellular signaling, and pathogenesis of diseases like cancer and neurodegenerative disorders. Researchers can leverage these cell lines to elucidate the molecular mechanisms of USP19-related pathways, thus facilitating drug discovery and the development of novel therapeutic strategies.

The scientific importance of USP19 Gene Knockout Cell Lines is exemplified by their application in both basic and translational research. They are invaluable tools for investigating drug targets, understanding therapeutics' mechanisms of action, and exploring the intricate network of gene regulation. Compared to alternative models, such as wild-type lines or less specific gene knockouts, these cell lines provide a more rigorous and conclusive understanding of gene function, assisting in the validation of potential biomarkers and treatments.

For researchers and clinicians, these cell lines offer distinct advantages, such as reproducibility, consistency, and ease of manipulation for various experimental setups. Their robustness in experimental conditions makes them a go-to choice in laboratories focused on elucidating complex biological mechanisms.

With a commitment to innovation and quality, our company specializes in providing advanced biological products that are rigorously developed and standardized. Our expertise in gene editing and cellular biology ensures that users receive not only high-quality research tools but also invaluable guidance for their experimental needs.

Please note that all services are for research use only. Not intended for any clinical use.

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