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USP14 Knockout Cell Lines

Gene: USP14

Official Full Name: ubiquitin specific peptidase 14provided by HGNC

Gene Summary: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12760 USP14 Knockout cell line (HeLa) Human USP14 1:3~1:6 Negative Online Inquiry
KO12761 USP14 Knockout cell line (HCT 116) Human USP14 1:2~1:4 Negative Online Inquiry
KO12762 USP14 Knockout cell line (HEK293) Human USP14 1:3~1:6 Negative Online Inquiry
KO12763 USP14 Knockout cell line (A549) Human USP14 1:3~1:4 Negative Online Inquiry

Background

USP14 Gene Knockout Cell Lines represent a significant advancement in the realm of cellular biology and genetic research. These specially engineered cell lines have undergone precise genomic editing to disrupt the expression of the USP14 gene, which encodes a deubiquitinating enzyme involved in regulating various cellular processes, including protein degradation, stress responses, and signal transduction pathways.

The primary function of the USP14 gene knockout cell lines is to facilitate the study of the role of USP14 in the ubiquitin-proteasome system and its implications in diseases such as cancer, neurodegenerative disorders, and other conditions characterized by protein misfolding. By blocking the gene’s activity, researchers can observe alterations in protein stability, turnover, and overall cellular homeostasis, deepening our understanding of the pathophysiological mechanisms underlying these diseases. Additionally, this tool can be utilized to identify potential therapeutic targets or biomarkers by analyzing compensatory cellular responses.

The scientific importance of USP14 knockout cell lines cannot be overstated, as they provide novel insights into the complexities of cellular regulation. Their applications extend to drug discovery and development, allowing for high-throughput screening to assess potential pharmacological agents’ efficacy against the backdrop of altered pathways influenced by the absence of USP14 activity.

What sets USP14 Gene Knockout Cell Lines apart from alternative models is their precision and reliability, backed by validated and reproducible results. These cell lines are rigorously characterized to ensure that users can achieve high-quality data, thus minimizing variability in experimental outcomes.

For researchers and clinicians aiming to elucidate the intricate relationships between protein regulation and disease pathology, the value of USP14 knockout cell lines is profound. They offer a unique platform for advancing both fundamental and applied biological research. Our company prides itself on its commitment to providing high-quality biological products backed by solid scientific foundations. We leverage leading-edge technology and expertise in genetic engineering to deliver tools that empower researchers in their quests to uncover the mysteries of cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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