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USP12 Knockout Cell Lines

Gene: USP12

Official Full Name: ubiquitin specific peptidase 12provided by HGNC

Gene Summary: Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in protein deubiquitination. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28870 USP12 Knockout cell line (HeLa) Human USP12 1:3~1:6 Negative Online Inquiry
KO28871 USP12 Knockout cell line (HCT 116) Human USP12 1:2~1:4 Negative Online Inquiry
KO28872 USP12 Knockout cell line (HEK293) Human USP12 1:3~1:6 Negative Online Inquiry
KO28873 USP12 Knockout cell line (A549) Human USP12 1:3~1:4 Negative Online Inquiry

Background

USP12 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular biology, specifically designed for the study of gene function and its implications in various physiological processes. These cell lines have been engineered to have a targeted disruption of the USP12 gene, which is crucial in the cellular ubiquitin-proteasome pathway, impacting processes such as protein degradation, cell cycle regulation, and responses to stressors. By eliminating the function of USP12, researchers can investigate the gene's role in cell proliferation, apoptosis, and potentially in oncogenesis.

The key function of USP12 Knockout Cell Lines is to facilitate deeper understanding of the molecular mechanisms underlying disease states. The loss of USP12 may lead to altered protein homeostasis and accumulation of polyubiquitinated proteins, thus providing insights into the pathways involved in tumorigenesis and other conditions where protein misregulation occurs. In research settings, these cell lines allow investigators to conduct functional assays, drug screening, and validate genetic targets for therapeutic intervention.

The scientific importance of the USP12 Gene Knockout Cell Lines lies in their broad applicability across various research domains, including cancer biology, neurobiology, and developmental biology. They offer a robust model to elucidate the coordinated functions of ubiquitin-dependent pathways as they pertain to cellular health and disease.

Unique advantages of our USP12 Gene Knockout Cell Lines include high specificity in the gene knockout process and validated consistency in experimental conditions, which can lead to reproducible results. Unlike conventional knockdown methods that may produce partial silencing, our knockout approach ensures complete gene disruption, enabling accurate assessments of gene function and downstream effects.

These cell lines are invaluable to researchers and clinicians aiming to develop targeted therapies and investigate the role of USP12 in disease. Our commitment to providing high-quality, genetically engineered cell lines stems from our expertise in molecular genetics and a strong dedication to advancing research in biological products. Trust in our rigorous validation processes and cutting-edge techniques to help pave the way for groundbreaking discoveries in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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