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UPF3A Knockout Cell Lines

Gene: UPF3A

Official Full Name: UPF3A regulator of nonsense mediated mRNA decayprovided by HGNC

Gene Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12795 UPF3A Knockout cell line (HeLa) Human UPF3A 1:3~1:6 Negative Online Inquiry
KO12796 UPF3A Knockout cell line (HCT 116) Human UPF3A 1:2~1:4 Negative Online Inquiry
KO12797 UPF3A Knockout cell line (HEK293) Human UPF3A 1:3~1:6 Negative Online Inquiry
KO12798 UPF3A Knockout cell line (A549) Human UPF3A 1:3~1:4 Negative Online Inquiry

Background

UPF3A Gene Knockout Cell Lines represent a groundbreaking advancement in cellular biology and genetic research, offering researchers a vital experimental model for studying gene function and regulation. These cell lines are specifically engineered to lack the UPF3A gene, which is essential for the nonsense-mediated mRNA decay (NMD) pathway, a critical cellular mechanism that ensures the degradation of faulty mRNA transcripts. By providing a system that eliminates UPF3A, these knockout cell lines facilitate in-depth exploration into the pathways that govern mRNA stability and the overall protein synthesis landscape.

The key function of UPF3A Gene Knockout Cell Lines lies in their ability to mimic and study the implications of disrupted NMD pathways, allowing investigators to observe changes in mRNA turnover and its downstream effects on gene expression. This capacity is particularly crucial in understanding various diseases where NMD plays a significant role, including certain genetic disorders and cancers. Researchers have the opportunity to investigate therapeutic strategies targeting aberrant mRNA processing, enhancing our comprehension of disease mechanisms and potential interventions.

What sets UPF3A Gene Knockout Cell Lines apart from other models is their specificity and consistency in research applications. They provide a reliable and reproducible system free from UPF3A interference, ensuring that experimental results accurately reflect changes attributed to the absence of this gene. Given their unique properties, these cell lines are invaluable for both basic research and clinical applications that aim to elucidate gene-related pathways influencing cell behavior.

In choosing our UPF3A Gene Knockout Cell Lines, researchers, and clinicians can enhance the precision of their studies, contributing meaningful insights into gene function and disease pathology. Our commitment to quality and innovation stems from extensive expertise in cellular and molecular biology, making us a trusted provider of sophisticated biological research tools. By integrating these cell lines into your research, you will undoubtedly unlock new possibilities in your scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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