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UHRF2 Knockout Cell Lines

Gene: UHRF2

Official Full Name: ubiquitin like with PHD and ring finger domains 2provided by HGNC

Gene Summary: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09288 UHRF2 Knockout cell line (HeLa) Human UHRF2 1:3~1:6 Negative Online Inquiry
KO09289 UHRF2 Knockout cell line (HCT 116) Human UHRF2 1:2~1:4 Negative Online Inquiry
KO09290 UHRF2 Knockout cell line (HEK293) Human UHRF2 1:3~1:6 Negative Online Inquiry
KO09291 UHRF2 Knockout cell line (A549) Human UHRF2 1:3~1:4 Negative Online Inquiry

Background

UHRF2 Gene Knockout Cell Lines are specialized biological tools designed to enhance gene function studies by enabling researchers to investigate the role of the UHRF2 gene in various cellular processes. UHRF2 (Ubiquitin-like, containing PHD and RING finger domains 2) is implicated in essential cellular mechanisms, including DNA methylation, histone modification, and cell cycle regulation. The knockout cell lines utilize CRISPR-Cas9 technology, which introduces precise genetic alterations that disrupt UHRF2 expression, allowing for the analysis of its physiological consequences in both sorted and bulk cell populations.

The mechanisms underlying the functionality of these knockout cell lines allow researchers to elucidate the effects of reduced or absent UHRF2 on gene expression, cell differentiation, and proliferation. By providing a model to study tumorigenesis and other pathologies where UHRF2 is active, these cell lines serve as a powerful platform for understanding the gene's impact on cellular health and disease.

In research and clinical settings, UHRF2 Gene Knockout Cell Lines are invaluable for drug discovery and development, as they enable the identification of potential therapeutic targets associated with UHRF2's regulatory role in tumor growth and metastasis. Moreover, their ability to mimic pathophysiological conditions allows for more accurate preclinical models.

What distinguishes UHRF2 Gene Knockout Cell Lines from alternatives is their specificity and efficiency. Traditional methods of gene knockdown often lead to incomplete silencing, whereas our cell lines ensure complete knockout, providing high reproducibility and reducing variability in experimental outcomes.

For researchers and clinicians focused on cancer biology, epigenetics, and cellular signaling pathways, the UHRF2 Gene Knockout Cell Lines are an essential resource that drives innovation in therapeutics and enhances our understanding of complex biological questions. Additionally, our company prides itself on its commitment to providing high-quality genetic tools backed by a team of expert scientists specializing in molecular biology, reinforcing our dedication to advancing research capabilities in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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