Gene: UBXN11
Official Full Name: UBX domain protein 11provided by HGNC
Gene Summary: This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00514 | UBXN11 gRNA1-gRNA2 KO plasmid | UBXN11 | $850 | |||
KO12835 | UBXN11 Knockout cell line (HeLa) | Human | UBXN11 | 1:3~1:6 | Negative | Online Inquiry |
KO12836 | UBXN11 Knockout cell line (HCT 116) | Human | UBXN11 | 1:2~1:4 | Negative | Online Inquiry |
KO12837 | UBXN11 Knockout cell line (HEK293) | Human | UBXN11 | 1:3~1:6 | Negative | Online Inquiry |
KO12838 | UBXN11 Knockout cell line (A549) | Human | UBXN11 | 1:3~1:4 | Negative | Online Inquiry |
UBXN11 Gene Knockout Cell Lines are genetically modified cellular models that have had the UBXN11 gene functionally disrupted using advanced CRISPR/Cas9 technology. This innovative product allows researchers to study the implications of UBXN11 gene loss on cellular processes, such as apoptosis, the cell cycle, and stress responses. UBXN11 is implicated in various biological functions, including the regulation of protein turnover and cellular homeostasis, making these knockout lines essential tools for understanding both fundamental biology and disease mechanisms.
These cell lines operate by lacking the UBXN11 gene, which leads to alterations in associated pathways and cellular behaviors. By comparing UBXN11 knockout cells to their wild-type counterparts, researchers can directly assess the gene’s role in specific cellular functions and its impact on various physiological and pathological processes. This system can facilitate the exploration of therapeutic approaches targeting UBXN11-related pathways, providing insights into potential interventions for conditions such as cancer and neurodegenerative diseases.
The significance of UBXN11 Gene Knockout Cell Lines extends to numerous research applications, including drug discovery, biomarker validation, and functional genomics. The ability to perform mechanistic studies in a controlled environment allows researchers to gather valuable data that can inform clinical research and therapeutic development.
What sets our UBXN11 Gene Knockout Cell Lines apart from other alternatives is the rigor of our validation process, ensuring high specificity and functionality of the knockout. Our commitment to quality guarantees reliable results that uphold the integrity of scientific investigations.
For researchers and clinicians alike, UBXN11 Gene Knockout Cell Lines represent a vital resource in the pursuit of groundbreaking discoveries. By facilitating a deeper understanding of gene function, our product promises to accelerate advancements in both basic and applied biological sciences. At [Your Company Name], we pride ourselves on our extensive expertise in developing high-quality biological products that meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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