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UBE2NL Knockout Cell Lines

Gene: UBE2NL

Official Full Name: ubiquitin conjugating enzyme E2 N like (gene/pseudogene)provided by HGNC

Gene Summary: This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12874 UBE2NL Knockout cell line (HeLa) Human UBE2NL 1:3~1:6 Negative Online Inquiry
KO12875 UBE2NL Knockout cell line (HCT 116) Human UBE2NL 1:2~1:4 Negative Online Inquiry
KO12876 UBE2NL Knockout cell line (HEK293) Human UBE2NL 1:3~1:6 Negative Online Inquiry
KO12877 UBE2NL Knockout cell line (A549) Human UBE2NL 1:3~1:4 Negative Online Inquiry

Background

UBE2NL Gene Knockout Cell Lines are specialized cellular models engineered to lack the UBE2NL gene, a critical component in the ubiquitin-proteasome pathway which regulates protein degradation and cellular homeostasis. These cell lines facilitate the study of various cellular processes by providing a platform to analyze the functional consequences of UBE2NL loss, thereby enabling researchers to dissect its role in signaling pathways, stress responses, and disease mechanisms.

The primary mechanism through which UBE2NL exerts its effect involves its interaction with other proteins involved in ubiquitination, influencing protein levels and activity within the cell. By knocking out this gene, researchers can directly observe changes in cellular dynamics, such as altered apoptosis rates, changes in protein turnover, and the modulation of cell cycle progression, providing invaluable insights into its biological significance.

The scientific importance of UBE2NL Gene Knockout Cell Lines extends into a variety of research fields, including cancer biology, neurobiology, and developmental biology. These cell lines can be instrumental in understanding diseases associated with protein misfolding and degradation, as well as aiding in the identification of potential therapeutic targets.

What sets our UBE2NL Gene Knockout Cell Lines apart from other alternatives is their unparalleled specificity and reliability. Each cell line is rigorously validated to ensure complete knockout of the UBE2NL gene, allowing for reproducible results in experiments. Additionally, these lines are available in various cell types, providing flexibility to researchers seeking to explore different biological contexts.

For researchers and clinicians focused on elucidating the complexities of cellular regulation and disease mechanisms, our UBE2NL Gene Knockout Cell Lines offer a unique, high-quality tool that can significantly enhance their experimental capabilities. With our extensive expertise in genetic engineering and commitment to advancing scientific research, we stand at the forefront of providing innovative biological solutions that meet the needs of our customers.

Please note that all services are for research use only. Not intended for any clinical use.

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