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UBE2D2 Knockout Cell Lines

Gene: UBE2D2

Official Full Name: ubiquitin conjugating enzyme E2 D2provided by HGNC

Gene Summary: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34874 UBE2D2 Knockout cell line (HeLa) Human UBE2D2 1:3~1:6 Negative Online Inquiry
KO34875 UBE2D2 Knockout cell line (HCT 116) Human UBE2D2 1:2~1:4 Negative Online Inquiry
KO34876 UBE2D2 Knockout cell line (HEK293) Human UBE2D2 1:3~1:6 Negative Online Inquiry
KO34877 UBE2D2 Knockout cell line (A549) Human UBE2D2 1:3~1:4 Negative Online Inquiry

Background

UBE2D2 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the UBE2D2 gene's role in various biological processes and diseases. These cell lines have undergone targeted genetic modifications to disrupt the expression of the UBE2D2 gene, a member of the ubiquitin-conjugating enzyme family, which plays a crucial role in protein degradation, signaling pathways, and the regulation of cellular homeostasis.

The key function of the UBE2D2 Gene Knockout Cell Lines lies in their ability to help researchers elucidate the molecular mechanisms whereby UBE2D2 influences protein turnover and cellular function. This is accomplished through the exploration of signaling cascades and the identification of substrate proteins that are modulated by UBE2D2 activity. By utilizing these knockout cells, scientists can investigate the downstream effects of UBE2D2 loss, thereby expanding our understanding of its implications in various diseases—most notably cancer and neurodegenerative disorders.

The scientific importance of UBE2D2 Gene Knockout Cell Lines is underscored in both research and clinical settings. They serve as vital tools for drug discovery, toxicity testing, and biomarker validation. With the global push toward targeted therapies, the ability to manipulate specific genes like UBE2D2 presents opportunities for more precise treatment approaches.

What sets our UBE2D2 Gene Knockout Cell Lines apart from alternative products is the rigorous validation process each cell line undergoes, ensuring consistent knockout efficiency and characterization. Furthermore, our cell lines are optimized for high reproducibility in experiments, which is of paramount importance in experimental design and data interpretation.

For researchers and clinicians seeking to advance their investigations, these cell lines represent an invaluable resource, enabling deeper insight into gene function and disease pathology. Our commitment to delivering high-quality biological products is backed by years of industry expertise and an unwavering dedication to supporting innovative research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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