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UBASH3B Knockout Cell Lines

Gene: UBASH3B

Official Full Name: ubiquitin associated and SH3 domain containing Bprovided by HGNC

Gene Summary: This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24384 UBASH3B Knockout cell line (HeLa) Human UBASH3B 1:3~1:6 Negative Online Inquiry
KO24385 UBASH3B Knockout cell line (HCT 116) Human UBASH3B 1:2~1:4 Negative Online Inquiry
KO24386 UBASH3B Knockout cell line (HEK293) Human UBASH3B 1:3~1:6 Negative Online Inquiry
KO24387 UBASH3B Knockout cell line (A549) Human UBASH3B 1:3~1:4 Negative Online Inquiry

Background

UBASH3B Gene Knockout Cell Lines are precisely engineered cellular models that facilitate the study of the UBASH3B gene's functional role in various biological processes. Utilizing advanced CRISPR/Cas9 gene-editing technology, these cell lines enable the complete disruption of the UBASH3B gene, which encodes an adaptor protein that plays critical roles in immune regulation, cellular signaling, and oncogenesis. By creating these knockout cell lines, researchers can investigate the resultant phenotypic and molecular changes, providing insights into the gene’s involvement in immune responses and its implications in diseases, including certain cancers and autoimmune disorders.

The key functionality of UBASH3B knockout cell lines lies in their ability to simulate the loss-of-function effects of the UBASH3B protein. This specifically allows scientists to elucidate the gene's role in downstream signaling pathways, cellular proliferation, and differentiation. Such functional assays using these knockout lines can lead to more targeted therapeutic strategies in oncology and immunology, providing critical data for developing novel interventions.

The scientific significance of these cell lines extends to both research and clinical settings, offering high utility for drug testing, biomarker discovery, and mechanistic studies of disease. Compared to traditional methods such as RNA interference, our UBASH3B knockout cell lines offer a more permanent and stable knockout, which is essential for long-term studies and provides a clearer understanding of gene function in the context of cell signaling.

Researchers and clinicians can greatly benefit from the precision and reliability that these cell lines bring to their work, enabling robust experimental designs and reproducible results. Our commitment to excellence in cellular model development underscores the reliability of these products for advancing scientific discovery in complex biological systems. With years of expertise in genetic engineering and a portfolio of high-quality biological tools, our company is dedicated to supporting the research community in unlocking the mysteries of gene function and its broader implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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