Gene: Tfap2a
Official Full Name: transcription factor AP-2, alphaprovided by MGI
Gene Summary: This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01489 | Tfap2a Knockout cell line(NIH/3T3) | Mouse | Tfap2a | 1:3~1:5 | Negative | Online Inquiry |
Tfap2a Gene Knockout Cell Lines are genetically modified cell lines in which the Tfap2a gene has been systematically disrupted, resulting in a loss of function of the transcription factor encoded by this gene. This product enables researchers to explore the biological significance and regulatory roles of the Tfap2a protein, which is implicated in critical developmental processes and cellular differentiation.
The primary functionality of these knockout cell lines lies in their capacity to elucidate the signaling pathways and gene expression networks influenced by Tfap2a. Through the removal of this specific gene, scientists can observe the resultant phenotypic changes and cellular responses, providing insights into the gene's role in embryonic development, immune response, and even oncogenic processes. Mechanistically, the absence of Tfap2a affects the transcriptional regulation of downstream genes, significantly impacting various cellular functions.
The scientific importance of Tfap2a knockout cell lines extends into both research and clinical settings. They are invaluable tools for studying developmental biology, epigenetics, and cancer biology, facilitating the development of targeted therapies and enhancing our understanding of gene function. Furthermore, these cell lines serve as a crucial platform for drug discovery and the validation of therapeutic targets.
What sets our Tfap2a Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility, ensuring that researchers can rely on consistent results across experiments. Our product is developed using cutting-edge CRISPR-Cas9 gene editing technology, providing unparalleled precision in gene disruption. This reliability, coupled with extensive characterization of the cell lines, positions them as a superior choice for scientists aiming for rigorous experimental accuracy.
For researchers, clinicians, or other target users, investing in Tfap2a Gene Knockout Cell Lines represents a significant opportunity to accelerate discoveries in gene function and regulation. With profound implications for regenerative medicine and cancer treatment, these cell lines are essential for advancing our collective understanding of biological processes.
Our company prides itself on its commitment to scientific excellence and innovation in biological products. We leverage advanced genetic engineering techniques and an extensive background in cell biology to deliver top-tier research tools that propel scientific inquiry forward.
Please note that all services are for research use only. Not intended for any clinical use.
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