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TXNDC5 Knockout Cell Lines

Gene: TXNDC5

Official Full Name: thioredoxin domain containing 5provided by HGNC

Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02636 TXNDC5 Knockout cell line (HeLa) Human TXNDC5 1:3~1:6 Negative Online Inquiry
KO02637 TXNDC5 Knockout cell line (HCT 116) Human TXNDC5 1:2~1:4 Negative Online Inquiry
KO02638 TXNDC5 Knockout cell line (HEK293) Human TXNDC5 1:3~1:6 Negative Online Inquiry
KO02639 TXNDC5 Knockout cell line (A549) Human TXNDC5 1:3~1:4 Negative Online Inquiry

Background

TXNDC5 Gene Knockout Cell Lines are precisely engineered mammalian cell lines designed to selectively disrupt the expression of the TXNDC5 gene, which is essential for cellular processes including protein folding and stress response. Utilizing CRISPR/Cas9 genome-editing technology, these cell lines provide researchers with a powerful tool to investigate the functional roles of TXNDC5 in various biological contexts.

The key function of TXNDC5 lies in its involvement in the endoplasmic reticulum's quality control system, where it aids in proper protein maturation and plays a vital role in maintaining redox homeostasis within the cell. By creating knockout models, scientists can explore the repercussions of the absence of TXNDC5 on cellular function, signaling pathways, and metabolic processes, which may contribute to understanding diseases related to protein misfolding, such as neurodegeneration and certain types of cancer.

The scientific importance of TXNDC5 Gene Knockout Cell Lines extends to both fundamental and applied research, offering insights into cellular stress mechanisms and potentially uncovering novel therapeutic targets. In clinical settings, these models can also facilitate drug discovery efforts, particularly in screening for compounds that may mitigate the effects of protein misfolding diseases.

Notably, the unique selling points of TXNDC5 Gene Knockout Cell Lines include their verified genetic modifications, reproducibility of results, and ease of integration into existing experimental workflows. Unlike traditional knockout methods that may display off-target effects or variability, the CRISPR/Cas9 approach ensures high specificity and efficiency, granting researchers confidence in their experimental outcomes.

For researchers and clinicians striving to push the boundaries of molecular biology and therapeutic development, the TXNDC5 Gene Knockout Cell Lines represent an invaluable, reliable resource. Our company specializes in delivering high-quality biological products supported by deep expertise in gene editing and cell line development, empowering your research with cutting-edge tools that are as robust as they are innovative.

Please note that all services are for research use only. Not intended for any clinical use.

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