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TUBB4B Knockout Cell Lines

Gene: TUBB4B

Official Full Name: tubulin beta 4B class IVbprovided by HGNC

Gene Summary: Enables double-stranded RNA binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in axonemal microtubule; intercellular bridge; and mitotic spindle. Implicated in Leber congenital amaurosis with early-onset deafness. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04958 TUBB4B Knockout cell line (HeLa) Human TUBB4B 1:3~1:6 Negative Online Inquiry
KO04959 TUBB4B Knockout cell line (HCT 116) Human TUBB4B 1:2~1:4 Negative Online Inquiry
KO04960 TUBB4B Knockout cell line (HEK293) Human TUBB4B 1:3~1:6 Negative Online Inquiry
KO04961 TUBB4B Knockout cell line (A549) Human TUBB4B 1:3~1:4 Negative Online Inquiry

Background

TUBB4B Gene Knockout Cell Lines are engineered cellular models wherein the TUBB4B gene, which encodes the beta-4B tubulin protein, has been systematically disrupted. This genetic manipulation leads to significant insights into cellular functions associated with microtubule dynamics and associated pathologies. The knockout of TUBB4B affects the stability and organization of microtubules, thereby influencing cell morphology, division, and intracellular transport processes.

These cell lines are invaluable tools in research settings focused on neurodegenerative diseases, cancer, and other disorders where microtubule stability plays a crucial role. By observing how the absence of TUBB4B affects cellular behavior, researchers can elucidate the mechanisms underlying various pathologies and identify potential therapeutic targets. The versatility of TUBB4B knockout cell lines enables their use across many experimental frameworks, including drug screening, gene expression studies, and cell signaling investigations.

Compared to conventional cell lines, TUBB4B knockout variants offer the unique advantage of a more authentic representation of disease states related to microtubule dysfunction. This specificity allows for more targeted experimental designs, ultimately leading to more robust and relevant data. Their well-characterized genetic background ensures reproducibility and reliability, critical factors for researchers and clinicians alike.

The importance of TUBB4B Gene Knockout Cell Lines extends beyond academia, as they facilitate the translation of basic research into potential clinical solutions for patients suffering from microtubule-related disorders. As an established leader in the field of biopharmaceuticals, our commitment at [Your Company Name] to quality and innovation ensures that our products, including TUBB4B knockout cell lines, are at the forefront of enabling groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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