Gene: TRPC4AP
Official Full Name: transient receptor potential cation channel subfamily C member 4 associated proteinprovided by HGNC
Gene Summary: Enables phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28286 | TRPC4AP Knockout cell line (HeLa) | Human | TRPC4AP | 1:3~1:6 | Negative | Online Inquiry |
KO28287 | TRPC4AP Knockout cell line (HCT 116) | Human | TRPC4AP | 1:2~1:4 | Negative | Online Inquiry |
KO28288 | TRPC4AP Knockout cell line (HEK293) | Human | TRPC4AP | 1:3~1:6 | Negative | Online Inquiry |
KO28289 | TRPC4AP Knockout cell line (A549) | Human | TRPC4AP | 1:3~1:4 | Negative | Online Inquiry |
TRPC4AP Gene Knockout Cell Lines represent a cutting-edge tool in the field of cellular and molecular biology, specifically designed to enable comprehensive functional studies of the TRPC4AP gene. These cell lines are genetically modified to lack the functional TRPC4AP gene, allowing researchers to investigate the downstream effects of this gene knockout on cellular processes. The TRPC4AP protein is implicated in various physiological and pathological processes, including cellular calcium signaling, making its study critical for understanding numerous biological pathways.
Key mechanisms of action for TRPC4AP Gene Knockout Cell Lines include the elimination of TRPC4AP-mediated signaling cascades, providing a clear context for observing resultant changes in cellular behavior, such as alterations in ion channel activity, cellular proliferation, and apoptosis. This knockout approach not only allows for the dissection of gene function but also enables the identification of compensatory mechanisms that may arise in the absence of TRPC4AP, thus offering deeper insights into cellular resilience and adaptation.
In the realm of scientific research and clinical applications, these knockout cell lines serve as invaluable platforms for drug discovery, target validation, and the understanding of disease mechanisms, particularly in conditions linked to ion transport dysregulation. Their utility extends to various applications, including studies on cardiomyopathies and neurodegenerative diseases, where TRPC4AP expression may be altered.
A standout feature of TRPC4AP Gene Knockout Cell Lines is their precision and reliability, contrasting with alternative methods such as RNA interference, which may produce off-target effects. Moreover, the consistency and reproducibility of findings using these knockout lines enhance the validity of experimental results, leading to robust conclusions.
The value of this product to researchers and clinicians lies in its capability to streamline experimental workflows and clarify gene function in complex biological systems. Additionally, our company, with its extensive experience in genetic engineering and commitment to advancing biomedical research, ensures that these cell lines are of the highest quality, enabling you to confidently explore the intricate biology surrounding the TRPC4AP gene and its implications in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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