Gene: TRIP6
Official Full Name: thyroid hormone receptor interactor 6provided by HGNC
Gene Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34934 | TRIP6 Knockout cell line (HeLa) | Human | TRIP6 | 1:3~1:6 | Negative | Online Inquiry |
KO34935 | TRIP6 Knockout cell line (HCT 116) | Human | TRIP6 | 1:2~1:4 | Negative | Online Inquiry |
KO34936 | TRIP6 Knockout cell line (HEK293) | Human | TRIP6 | 1:3~1:6 | Negative | Online Inquiry |
KO34937 | TRIP6 Knockout cell line (A549) | Human | TRIP6 | 1:3~1:4 | Negative | Online Inquiry |
TRIP6 Gene Knockout Cell Lines are genetically engineered cell models that have had the TRIP6 gene specifically disrupted or "knocked out." The TRIP6 gene encodes a protein involved in various cellular processes, including cytoskeletal organization and cell signaling pathways. By utilizing these knockout cell lines, researchers can observe the effects of TRIP6 deficiency, enabling them to elucidate its role in processes such as cell adhesion, migration, and proliferation.
The key function of TRIP6 includes the modulation of integrin signaling, which is crucial for cellular interactions with the extracellular matrix. By employing TRIP6 Gene Knockout Cell Lines, scientists can investigate how the absence of this gene alters cellular behavior, contributing to a deeper understanding of various diseases including cancer, fibrosis, and other disorders characterized by aberrant cell signaling. Additionally, these cell lines provide an essential platform for validating therapeutic targets, allowing for the screening of drug candidates that interact with the integrin signaling pathway.
The scientific importance of TRIP6 Gene Knockout Cell Lines lies in their ability to serve as a powerful tool for dissecting complex biological mechanisms and providing insights into disease mechanisms. Their application is invaluable in both fundamental research and translational medicine, as they can help in identifying biomarkers or potential drug targets.
Compared to traditional cell lines, TRIP6 Gene Knockout Cell Lines offer distinct advantages, such as the ability to study gene function in a controlled manner, leading to more precise experimental outcomes. These models provide a reliable means to explore the effects of TRIP6 deficiency without the confounding variables typically associated with partial gene inhibition or wild-type models.
For researchers and clinicians focused on understanding the molecular underpinnings of diseases, TRIP6 Gene Knockout Cell Lines present a valuable resource. Their use can accelerate discoveries and foster innovative approaches in therapeutic development, paving the way for improved patient outcomes.
With our extensive expertise in cellular biology and genetic engineering, we are committed to delivering high-quality biological products that meet the rigorous standards of scientific research. Our TRIP6 Gene Knockout Cell Lines are produced under stringent conditions, ensuring reliability and reproducibility for all your experimental needs.
Please note that all services are for research use only. Not intended for any clinical use.
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