Gene: TRIM3
Official Full Name: tripartite motif containing 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31674 | TRIM3 Knockout cell line (HeLa) | Human | TRIM3 | 1:3~1:6 | Negative | Online Inquiry |
KO31675 | TRIM3 Knockout cell line (HCT 116) | Human | TRIM3 | 1:2~1:4 | Negative | Online Inquiry |
KO31676 | TRIM3 Knockout cell line (HEK293) | Human | TRIM3 | 1:3~1:6 | Negative | Online Inquiry |
KO31677 | TRIM3 Knockout cell line (A549) | Human | TRIM3 | 1:3~1:4 | Negative | Online Inquiry |
TRIM3 Gene Knockout Cell Lines are specialized cellular models where the TRIM3 gene has been inactivated through precise genome editing techniques. TRIM3, a member of the tripartite motif (TRIM) family, is known for its role in various cellular processes, such as protein ubiquitination and downregulation of signaling pathways. The knockout of TRIM3 allows researchers to investigate its functional roles within cellular contexts, helping to elucidate mechanisms related to neurodegenerative diseases, cancer, and immune responses.
These cell lines facilitate an enhanced understanding of TRIM3's involvement in protein homeostasis and cellular stress responses. By providing a model in which the TRIM3 protein is absent, scientists can assess the downstream effects on cellular signaling, gene expression, and protein interactions. This is particularly vital in exploring the pathological implications associated with altered TRIM3 activity, offering insights that could lead to novel therapeutic approaches.
Compared to traditional knockout methods, which often involve time-consuming and variable processes, our TRIM3 Gene Knockout Cell Lines are generated using CRISPR-Cas9 technology, offering high efficiency and specificity. Researchers benefit from these consistent models, which are readily available for study and validation of experimental hypotheses. The precision and reproducibility of these cell lines significantly enhance experimental outcomes, making them a superior choice for scientists focused on gene function analysis.
The value of TRIM3 Gene Knockout Cell Lines extends beyond basic research; they are invaluable in drug discovery and development, allowing for the identification and validation of potential therapeutic targets. Our commitment to quality ensures that these cell lines are rigorously tested and validated, providing researchers and clinicians with reliable and relevant tools to advance their work. With extensive expertise in gene editing technologies, our company is dedicated to delivering innovative biological products that empower scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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