Gene: TRIM24
Official Full Name: tripartite motif containing 24provided by HGNC
Gene Summary: The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00453 | TRIM24 knockout cell line (A549) | Human | TRIM24 | 1:3~1:4 | Negative | Online Inquiry |
KO33825 | TRIM24 Knockout cell line (HeLa) | Human | TRIM24 | 1:3~1:6 | Negative | Online Inquiry |
KO33826 | TRIM24 Knockout cell line (HCT 116) | Human | TRIM24 | 1:2~1:4 | Negative | Online Inquiry |
KO33827 | TRIM24 Knockout cell line (HEK293) | Human | TRIM24 | 1:3~1:6 | Negative | Online Inquiry |
TRIM24 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the functional role of the TRIM24 gene, which encodes a protein implicated in diverse biological processes, including transcription regulation, cellular signaling, and oncogenesis. By employing CRISPR-Cas9 technology, these knockout cell lines achieve precise modification of the TRIM24 gene, allowing for the elucidation of its unique contributions to cellular homeostasis and disease pathology.
The primary mechanism of action involves the complete disruption of the TRIM24 gene, which not only aids in determining the gene’s essential functions but also facilitates the generation of an ideal platform for assessing the impact of TRIM24 on various signaling pathways. Researchers can observe alterations in gene expression profiles, cellular growth patterns, and responses to external stimuli, which can significantly enhance our understanding of its role in cancer and other diseases.
The scientific importance of TRIM24 Gene Knockout Cell Lines lies in their potential applications across research and clinical settings, particularly in cancer research, epigenetics, and drug development. By understanding TRIM24's involvement in tumorigenesis and other cellular processes, researchers can identify novel therapeutic targets and biomarkers, ultimately contributing to the advancement of precision medicine.
Compared to traditional cell line models, our TRIM24 Gene Knockout Cell Lines offer higher specificity and reproducibility in experimental results, which lead to more reliable data and insights. This precision significantly reduces the risk of off-target effects and improves the validity of findings, setting these lines apart from competitors.
For researchers and clinicians focused on the interplay between gene expression and disease outcomes, our TRIM24 Gene Knockout Cell Lines are invaluable tools. They provide the capability to explore fundamental biological questions while also paving the way for potential clinical innovations. Our company prides itself on its expertise in developing high-quality biological products, ensuring that our TRIM24 Gene Knockout Cell Lines meet rigorous scientific standards, thereby empowering researchers to unlock the intricacies of gene function and disease mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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