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TPK1 Knockout Cell Lines

Gene: TPK1

Official Full Name: thiamin pyrophosphokinase 1provided by HGNC

Gene Summary: The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27911 TPK1 Knockout cell line (HeLa) Human TPK1 1:3~1:6 Negative Online Inquiry
KO27912 TPK1 Knockout cell line (HCT 116) Human TPK1 1:2~1:4 Negative Online Inquiry
KO27913 TPK1 Knockout cell line (HEK293) Human TPK1 1:3~1:6 Negative Online Inquiry
KO27914 TPK1 Knockout cell line (A549) Human TPK1 1:3~1:4 Negative Online Inquiry

Background

TPK1 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the exploration of the TPK1 gene's functions and its implications in various biological processes. TPK1, or Thiamine Pyrophosphate Kinase 1, is a critical enzyme involved in thiamine metabolism and energy production. By creating efficient knockout models, researchers can diminish or eliminate the expression of the TPK1 gene, allowing for in-depth studies on its role in cellular metabolism, growth regulation, and potential contributions to pathologies such as metabolic disorders.

The key function of TPK1 Gene Knockout Cell Lines is their ability to serve as a platform for functional genomics and phenotypic analysis. These cell lines operate with a disrupted TPK1 gene, providing insights into metabolic pathways and cellular stress responses triggered by thiamine deficiency. Researchers can employ these models to elucidate mechanisms of disease, screen for drug candidates, or investigate novel therapeutic strategies targeting metabolic dysregulation.

Scientifically, TPK1 knockout lines hold substantial importance within both research and clinical frameworks. They provide a unique opportunity to better understand the intricate connections between energetics, metabolism, and disease states, particularly in the context of conditions deranged by metabolic dysfunction. This can lead to the identification of novel biomarkers or therapeutic targets, fostering advancements in precision medicine.

One of the primary advantages of TPK1 Gene Knockout Cell Lines is their specificity and reproducibility. Unlike alternative methods that may employ pharmacological inhibitors or transfection strategies, the knockout approach offers a stable and consistent gene disruption that enables long-term studies. This decreases variability in experimental outcomes and enhances the reliability of data generated in research settings.

For researchers and clinicians alike, the value of TPK1 Gene Knockout Cell Lines is profound; they support foundational studies that can translate into clinical insights and therapeutic applications. By integrating these models into your research, you empower your work to drive innovative discoveries and better understand the complex dynamics of cellular metabolism.

Our company is at the forefront of providing cutting-edge biological products, with a commitment to delivering scientifically validated and rigorously tested cell lines that enhance research productivity and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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