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TPCN2 Knockout Cell Lines

Gene: TPCN2

Official Full Name: two pore segment channel 2provided by HGNC

Gene Summary: This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00128 TPCN2 Knockout cell line (T98G) Human TPCN2 1:2-1:4 Negative Online Inquiry
KO00900 TPCN2 Knockout cell line(Jurkat) Human TPCN2 1:3-1:5 Negative Online Inquiry
KO08024 TPCN2 Knockout cell line (HeLa) Human TPCN2 1:3~1:6 Negative Online Inquiry
KO08025 TPCN2 Knockout cell line (HCT 116) Human TPCN2 1:2~1:4 Negative Online Inquiry
KO08026 TPCN2 Knockout cell line (HEK293) Human TPCN2 1:3~1:6 Negative Online Inquiry
KO08027 TPCN2 Knockout cell line (A549) Human TPCN2 1:3~1:4 Negative Online Inquiry

Background

TPCN2 Gene Knockout Cell Lines are specially engineered cellular models in which the TPCN2 gene has been selectively disrupted or "knocked out." This innovative product is designed to assist researchers in elucidating the biological functions and pathways associated with the TPCN2 gene, which encodes for a translator protein involved in various cellular processes, including calcium signaling and membrane transport. By utilizing these knockout cell lines, scientists can gain critical insights into cellular behavior under the influence of TPCN2 absence, thereby facilitating a deeper understanding of its role in pathologies such as cancer, neurodegenerative diseases, and cardiovascular disorders.

The primary mechanism of action for TPCN2 knockout relies on the absence of protein translation and expression from the target gene, enabling investigators to observe resulting phenotypic changes and alterations in cellular signaling pathways. This method provides a powerful tool for examining the effects of TPCN2 on ion homeostasis, autophagy, and cell survival, allowing for comprehensive studies that could lead to novel therapeutic approaches.

In scientific research and clinical settings, TPCN2 Gene Knockout Cell Lines are pivotal. Their applications extend to pharmacological screening, disease modeling, and gene function studies, where understanding the consequent cellular adaptations due to TPCN2 loss can yield critical data for developing targeted interventions.

What sets our TPCN2 Gene Knockout Cell Lines apart from traditional models is their specificity and reliability. Unlike other genetic alteration approaches, our knockout cell lines provide a clean background devoid of off-target effects, ensuring robustness in experimental outcomes. Furthermore, our comprehensive quality control process guarantees high reproducibility and consistency across batches, supporting the validity of research findings.

For researchers and clinicians, investing in TPCN2 Gene Knockout Cell Lines translates to enhanced experimental accuracy and the potential for groundbreaking discoveries in gene function and therapeutic strategies. With our extensive experience and commitment to advancing biological research tools, our company offers exceptional expertise and support, solidifying our position as a leader in the field of genetic engineering and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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