Gene: TOR1AIP1
Official Full Name: torsin 1A interacting protein 1provided by HGNC
Gene Summary: This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28357 | TOR1AIP1 Knockout cell line (HeLa) | Human | TOR1AIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO28358 | TOR1AIP1 Knockout cell line (HCT 116) | Human | TOR1AIP1 | 1:2~1:4 | Negative | Online Inquiry |
KO28359 | TOR1AIP1 Knockout cell line (HEK293) | Human | TOR1AIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO28360 | TOR1AIP1 Knockout cell line (A549) | Human | TOR1AIP1 | 1:3~1:4 | Negative | Online Inquiry |
TOR1AIP1 Gene Knockout Cell Lines are specialized genetic models engineered to lack functional TOR1AIP1 gene expression, pivotal in the study of various cellular processes and disease mechanisms. These cell lines serve as invaluable tools for researchers investigating the roles of TOR1AIP1 in cellular signaling pathways, cellular stress responses, and neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington’s disease.
The TOR1AIP1 protein is involved in key cellular functions, particularly in the context of the chaperone-mediated pathway and the maintenance of mitochondrial function. By utilizing these knockout cell lines, scientists can elucidate the compensatory mechanisms that cells employ in the absence of TOR1AIP1, providing insights into the underlying molecular dysfunctions that may lead to disease. The knockout model allows for a synchronized environment to assess gene function and interaction without the confounding variables often present in wild-type systems.
In terms of scientific importance, these cell lines find applications in basic and applied research settings, offering a robust platform for drug discovery and the development of therapeutic interventions. They can facilitate high-throughput screening of candidate compounds that may restore normal cellular function or inhibit aberrant pathways associated with TOR1AIP1 depletion.
Compared to traditional cell lines or models, the TOR1AIP1 Gene Knockout Cell Lines afford researchers a more precise means to investigate gene function in a controlled environment, minimizing background noise. The specificity of gene knockout facilitates clearer results and allows for more straightforward interpretation of experimental outcomes.
For researchers and clinicians alike, these cell lines represent cutting-edge tools that deepen our understanding of complex biological systems. They empower investigators to push the boundaries of current knowledge and contribute to the advancement of novel treatment strategies.
Our company is dedicated to providing high-quality biological products and tools that support innovative research. With our expertise in gene knockout technologies, we are committed to advancing scientific discovery and enhancing the capabilities of researchers worldwide.
Please note that all services are for research use only. Not intended for any clinical use.
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