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TOMM5 Knockout Cell Lines

Gene: TOMM5

Official Full Name: translocase of outer mitochondrial membrane 5provided by HGNC

Gene Summary: Predicted to be involved in protein insertion into mitochondrial outer membrane. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21352 TOMM5 Knockout cell line (HeLa) Human TOMM5 1:3~1:6 Negative Online Inquiry
KO21353 TOMM5 Knockout cell line (HCT 116) Human TOMM5 1:2~1:4 Negative Online Inquiry
KO21354 TOMM5 Knockout cell line (HEK293) Human TOMM5 1:3~1:6 Negative Online Inquiry
KO21355 TOMM5 Knockout cell line (A549) Human TOMM5 1:3~1:4 Negative Online Inquiry

Background

TOMM5 Gene Knockout Cell Lines are genetically modified cell cultures designed to specifically disrupt the TOMM5 gene, which encodes a protein central to mitochondrial function. These knockout cell lines serve as essential tools for studying mitochondrial biology and the broader implications of mitochondrial dysfunction in various diseases, including neurodegenerative disorders and metabolic syndromes. By excising the TOMM5 gene, researchers create a model to examine the consequences of its absence on cellular metabolism, oxidative stress responses, and overall cell viability.

The primary mechanism behind this product lies in the use of CRISPR-Cas9 technology, enabling precise genomic alterations that facilitate the exploration of gene function in a controlled manner. By utilizing TOMM5 gene knockout cell lines, scientists can investigate the role of mitochondrial proteins in apoptosis, energy production, and cellular signaling pathways, thereby broadening our understanding of cell physiology and pathology.

The significance of these cell lines extends beyond fundamental research as they can be instrumental in drug discovery and development, particularly for therapies targeting mitochondrial diseases. Researchers can assess how potential compounds interact with cellular systems lacking TOMM5, providing insights into therapeutic efficacy and safety.

What sets TOMM5 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. Unlike traditional knockout models that may show unintended compensatory mechanisms, these cell lines offer a more precise platform for experimental reproducibility. Their ease of use and adaptability for various assays make them superior for both in vitro studies and potential translational research.

For researchers and clinicians aiming to understand and combat mitochondrial dysfunction, TOMM5 Gene Knockout Cell Lines represent a valuable asset in the pursuit of innovative solutions. Our company's expertise in gene editing technologies and commitment to delivering high-quality biological products ensures that you will have access to cutting-edge tools that foster groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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