Gene: TNRC6B
Official Full Name: trinucleotide repeat containing adaptor 6Bprovided by HGNC
Gene Summary: Enables RNA binding activity. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29831 | TNRC6B Knockout cell line (HeLa) | Human | TNRC6B | 1:3~1:6 | Negative | Online Inquiry |
KO29832 | TNRC6B Knockout cell line (HCT 116) | Human | TNRC6B | 1:2~1:4 | Negative | Online Inquiry |
KO29833 | TNRC6B Knockout cell line (HEK293) | Human | TNRC6B | 1:3~1:6 | Negative | Online Inquiry |
KO29834 | TNRC6B Knockout cell line (A549) | Human | TNRC6B | 1:3~1:4 | Negative | Online Inquiry |
TNRC6B Gene Knockout Cell Lines are innovative cellular models specifically designed to investigate the role of the TNRC6B gene in gene silencing and post-transcriptional regulation. Through the targeted knockout of the TNRC6B gene, these cell lines facilitate the study of how RNA-induced silencing complexes (RISC) regulate messenger RNA stability and translation, offering a powerful tool for elucidating the mechanisms underlying gene expression modulation in various biological contexts.
The key function of TNRC6B knockout cell lines lies in their ability to provide insight into the pathways associated with RNA interference and the decay of mRNA. By analyzing these cell lines, researchers can dissect the effects of TNRC6B loss on various cellular processes, including tumorigenesis, inflammatory responses, and other dynamic gene regulatory networks. This insight is pivotal for understanding the cellular consequences of dysregulated RNA metabolism in disease states.
In both research and clinical settings, TNRC6B knockout cell lines have extensive applications, from exploring the biological underpinnings of diseases to developing novel therapeutic strategies that target gene regulation. They allow for high-throughput screening of small molecules or genetic manipulations aimed at restoring normal RISC function, presenting opportunities for advances in gene therapy and personalized medicine.
What sets our TNRC6B Gene Knockout Cell Lines apart from alternatives is their robust validation through CRISPR-Cas9 technology, ensuring precise genomic modifications and consistent expression profiles. Furthermore, these cell lines are derived from various tissue types, making them adaptable for a range of experiments across multiple environments.
For researchers and clinicians seeking dependable models to explore gene function and regulation, our TNRC6B knockout cell lines represent a valuable addition to their toolkit, enhancing the understanding of gene regulatory mechanisms and contributing to cutting-edge discoveries. With extensive expertise in biotechnological innovations, our company is committed to providing high-quality cellular models that empower research and drive advancements in health and disease understanding.
Please note that all services are for research use only. Not intended for any clinical use.
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