Gene: TNNT1
Official Full Name: troponin T1, slow skeletal typeprovided by HGNC
Gene Summary: This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13124 | TNNT1 Knockout cell line (HeLa) | Human | TNNT1 | 1:3~1:6 | Negative | Online Inquiry |
KO13125 | TNNT1 Knockout cell line (HCT 116) | Human | TNNT1 | 1:2~1:4 | Negative | Online Inquiry |
KO13126 | TNNT1 Knockout cell line (HEK293) | Human | TNNT1 | 1:3~1:6 | Negative | Online Inquiry |
KO13127 | TNNT1 Knockout cell line (A549) | Human | TNNT1 | 1:3~1:4 | Negative | Online Inquiry |
TNNT1 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the functions of the troponin T type 1 (TNNT1) gene, which plays a crucial role in muscle contraction. Through comprehensive CRISPR/Cas9 gene-editing techniques, these cell lines have been rendered deficient in TNNT1, allowing researchers to dissect the physiological and pathological implications of this gene's absence on muscle functionality.
The primary function of these knockout cell lines is to serve as a controlled environment for examining muscle-related diseases, specifically those linked to troponin T dysfunctions, such as certain forms of cardiomyopathy and muscular dystrophies. By observing the phenotypic outcomes and cellular processes in the absence of TNNT1, scientists can gain insights into the mechanistic pathways that govern muscle contractility, as well as potential compensatory mechanisms activated in the context of muscle pathologies.
The scientific importance of TNNT1 Gene Knockout Cell Lines extends into both research and clinical settings. They represent valuable tools for the development of novel therapeutic strategies aimed at muscle disorders, enabling drug discovery and testing in a relevant biological context. Furthermore, these cell lines can facilitate high-throughput screening of compounds that may ameliorate the effects of TNNT1 deficiency.
Each cell line is meticulously validated to ensure specificity and reliability, positioning it as a superior alternative to traditional models that often lack the necessary genetic precision. Unlike alternatives, such as overexpression systems or heterologous models, TNNT1 Gene Knockout Cell Lines provide a direct means to study gene loss-of-function consequences, empowering researchers to draw more accurate biological conclusions.
This product is invaluable to researchers and clinicians striving to unravel the complexities of muscle diseases and enhance therapeutic interventions. Providing essential insights into gene function, these cell lines represent a pivotal resource in the quest for innovative treatments.
Our company specializes in high-quality biological products, underscoring our commitment to advancing research and clinical solutions. We offer an unparalleled range of genetic models and services tailored to meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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