Gene: TNK2
Official Full Name: tyrosine kinase non receptor 2provided by HGNC
Gene Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32140 | TNK2 Knockout cell line (HeLa) | Human | TNK2 | 1:3~1:6 | Negative | Online Inquiry |
KO32141 | TNK2 Knockout cell line (HCT 116) | Human | TNK2 | 1:2~1:4 | Negative | Online Inquiry |
KO32142 | TNK2 Knockout cell line (HEK293) | Human | TNK2 | 1:3~1:6 | Negative | Online Inquiry |
KO32143 | TNK2 Knockout cell line (A549) | Human | TNK2 | 1:3~1:4 | Negative | Online Inquiry |
TNK2 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically inactivate the TNK2 gene, which encodes the tyrosine kinase 2, a critical component in various signaling pathways, including those involved in immune response and cell proliferation. This gene knockout is achieved through advanced techniques such as CRISPR/Cas9 or homologous recombination, allowing researchers to study the physiological role of TNK2 in cellular homeostasis and pathology.
Key functions of TNK2 include modulation of oncogenic signaling and engagement in immune receptor signaling pathways. By utilizing these knockout cell lines, researchers can dissect the downstream effects of TNK2 ablation, contributing to a better understanding of diseases such as cancer, autoimmune disorders, and viral infections. The manipulation of this gene allows the exploration of its role in tumorigenesis, making these models invaluable in preclinical studies focused on targeted therapies and biomarker discovery.
The scientific importance of TNK2 Gene Knockout Cell Lines lies in their capacity to elucidate the mechanism of action of potential therapeutics and to validate targets in drug discovery pipelines. Their use in translational research settings facilitates the bridging of basic science with clinical applications, ensuring that findings can be rapidly translated into real-world therapies.
Compared to alternative models, such as wild-type cell lines, TNK2 knockout variants offer a clear advantage by providing insights into gene function without confounding background signals. This specificity allows for more accurate hypothesis testing and reproducibility in experimental designs, streamlining the path to new discoveries.
For researchers and clinicians, investing in TNK2 Gene Knockout Cell Lines represents a strategic move towards understanding and treating diseases at a molecular level. The ability to dissect the role of specific genes in critical pathways can lead to breakthroughs in therapeutic applications, enhancing both the understanding and treatment of complex diseases.
At [Your Company Name], we are committed to advancing research and innovation in the life sciences sector through our high-quality, precision-engineered biological products. Our team of experts ensures that every product, including the TNK2 Gene Knockout Cell Lines, meets rigorous scientific standards, empowering researchers to drive their studies forward with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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