Gene: TNIP2
Official Full Name: TNFAIP3 interacting protein 2provided by HGNC
Gene Summary: This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20744 | TNIP2 Knockout cell line (HeLa) | Human | TNIP2 | 1:3~1:6 | Negative | Online Inquiry |
KO20745 | TNIP2 Knockout cell line (HCT 116) | Human | TNIP2 | 1:2~1:4 | Negative | Online Inquiry |
KO20746 | TNIP2 Knockout cell line (HEK293) | Human | TNIP2 | 1:3~1:6 | Negative | Online Inquiry |
KO20747 | TNIP2 Knockout cell line (A549) | Human | TNIP2 | 1:3~1:4 | Negative | Online Inquiry |
TNIP2 Gene Knockout Cell Lines are specialized cellular models engineered to eliminate the expression of the TNIP2 gene, facilitating the study of its role in various biological processes and pathological conditions. This innovative product enables researchers to investigate the functions of TNIP2 in cellular signaling, inflammation, and immune responses, providing critical insights into its contributions to human health and disease.
The mechanism of action involves targeted gene disruption through advanced CRISPR-Cas9 technology, which induces double-strand breaks in the TNIP2 gene locus. This results in frameshift mutations that render the gene nonfunctional, allowing researchers to observe the resultant phenotypic and molecular changes. Utilizing TNIP2 knockout cell lines facilitates the dissection of TNIP2's impact on critical cellular pathways, including NF-κB signaling, thus providing a powerful tool for both basic and applied research.
Scientifically, the TNIP2 Gene Knockout Cell Lines are invaluable for investigating the roles of TNIP2 in diverse areas such as cancer biology, autoimmune diseases, and metabolic disorders. They are particularly important in clinical settings for elucidating therapeutic targets and evaluating the effectiveness of novel interventions aimed at modulating TNIP2-related pathways.
Compared to traditional knockout models, our TNIP2 Gene Knockout Cell Lines offer several distinct advantages, including a more rapid development timeline and higher efficiency, thanks to precise gene editing. Furthermore, researchers benefit from the immediate availability of ready-to-use, consistent cell lines that are amenable to various experimental conditions. The ease of application and reproducibility enhances their utility in high-throughput screening and drug discovery efforts.
In conclusion, the TNIP2 Gene Knockout Cell Lines represent a cutting-edge resource for researchers and clinicians seeking to advance their work in molecular biology and therapeutics. Our commitment to scientific expertise and innovation underpins the quality of our products, ensuring that users can rely on our offerings to drive their research forward effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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