Gene: TMTC1
Official Full Name: transmembrane O-mannosyltransferase targeting cadherins 1provided by HGNC
Gene Summary: Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05744 | TMTC1 Knockout cell line (HeLa) | Human | TMTC1 | 1:3~1:6 | Negative | Online Inquiry |
KO05745 | TMTC1 Knockout cell line (HEK293) | Human | TMTC1 | 1:3~1:6 | Negative | Online Inquiry |
TMTC1 Gene Knockout Cell Lines are genetically modified cell lines specifically developed to disable the TMTC1 gene, which encodes a member of the transmembrane and tetratricopeptide repeats containing 1 protein family. The targeted knockout of this gene allows for the in-depth study of its functional role in various cellular processes and disease states. By utilizing CRISPR-Cas9 gene-editing technology, these cell lines represent a powerful tool for elucidating the biological pathways influenced by TMTC1 and its potential implications in human health and disease.
The primary mechanism driving the utility of TMTC1 Gene Knockout Cell Lines lies in their ability to facilitate loss-of-function studies. Researchers can employ these cell lines to assess how the absence of TMTC1 affects cellular behavior, signaling pathways, and phenotypic traits. This is particularly important in understanding the protein's role in pathological conditions such as neurodegenerative diseases and cancer, where TMTC1 might exhibit regulatory functions.
In research and clinical settings, these knockout cell lines are invaluable for high-throughput screening and drug development, enabling scientists to identify novel therapeutic targets or biomarkers associated with TMTC1 modulation. Compared to wild-type cell lines, TMTC1 knockout variants provide a clear, controlled system to dissect gene function and evaluate therapeutic efficacy, enhancing the reliability of experimental outcomes.
One of the key advantages of TMTC1 Gene Knockout Cell Lines is their specificity and ease of use in various assays, including cellular assays, gene expression studies, and proteomic analyses. This allows researchers to manipulate experimental conditions more precisely and draw more robust conclusions. Moreover, the availability of these cell lines supports reproducibility and comparability across studies, a critical factor in advancing scientific research.
For researchers and clinicians engaged in cutting-edge genomics and molecular biology, TMTC1 Gene Knockout Cell Lines are a valuable asset that can significantly contribute to the understanding of gene function and its implications in health and disease. Our company is dedicated to providing high-quality biological products that enhance research capabilities, and we pride ourselves on our extensive expertise in genetic modifications and cell line development, ensuring that our products meet the highest standards for reliability and performance in scientific investigation.
Please note that all services are for research use only. Not intended for any clinical use.
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