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TMEM53 Knockout Cell Lines

Gene: TMEM53

Official Full Name: transmembrane protein 53provided by HGNC

Gene Summary: Involved in negative regulation of BMP signaling pathway; negative regulation of ossification; and regulation of nucleocytoplasmic transport. Located in nuclear membrane. Implicated in craniotubular dysplasia Ikegawa type. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13307 TMEM53 Knockout cell line (HeLa) Human TMEM53 1:3~1:6 Negative Online Inquiry
KO13308 TMEM53 Knockout cell line (HCT 116) Human TMEM53 1:2~1:4 Negative Online Inquiry
KO13309 TMEM53 Knockout cell line (HEK293) Human TMEM53 1:3~1:6 Negative Online Inquiry
KO13310 TMEM53 Knockout cell line (A549) Human TMEM53 1:3~1:4 Negative Online Inquiry

Background

TMEM53 Gene Knockout Cell Lines are specifically engineered cells in which the TMEM53 gene has been inactivated, allowing researchers to study the gene's function and its role in various biological processes. The TMEM53 gene is implicated in several cellular mechanisms, including membrane trafficking, signal transduction, and cellular stress responses. By employing a knockout strategy, these cell lines enable scientists to elucidate the pathways influenced by TMEM53 and identify phenotypic changes resulting from its absence.

The primary function of these knockout cell lines lies in their application as robust models to investigate the physiological and pathological implications of TMEM53. The gene knockout is achieved through advanced genome editing technologies, such as CRISPR-Cas9, resulting in a loss of function that can be rigorously assessed in various experimental setups. This provides researchers a powerful tool for studying disease mechanisms, particularly in cancer and metabolic disorders, where TMEM53 may play a significant role.

The scientific importance of TMEM53 Gene Knockout Cell Lines extends into both basic research and translational applications. In research, they facilitate the understanding of gene regulation, protein interactions, and cellular behavior upon loss of TMEM53 function. Clinically, these cell lines have the potential to contribute to the identification of novel therapeutic targets, enabling the development of innovative treatments for diseases related to dysfunctional membrane processes.

Compared to traditional cell lines, TMEM53 knockout models offer distinct advantages, including higher specificity in gene function studies and reduced variability in experimental outcomes. These lines are meticulously validated for gene knockout efficiency and phenotypic consistency, ensuring reliable data for downstream applications. Researchers and clinicians will find these cell lines valuable for drug discovery, biomarker identification, and functional genomics studies.

With a strong background in genetic engineering and an unwavering commitment to advancing biological research, our company specializes in providing high-quality, precisely designed cell lines tailored to the needs of the scientific community. Through our expertise and innovative offerings, we aim to empower researchers and clinicians to make groundbreaking discoveries that can significantly impact human health.

Please note that all services are for research use only. Not intended for any clinical use.

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