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TMEM185A Knockout Cell Lines

Gene: TMEM185A

Official Full Name: transmembrane protein 185Aprovided by HGNC

Gene Summary: The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24804 TMEM185A Knockout cell line (HeLa) Human TMEM185A 1:3~1:6 Negative Online Inquiry
KO24805 TMEM185A Knockout cell line (HCT 116) Human TMEM185A 1:2~1:4 Negative Online Inquiry
KO24806 TMEM185A Knockout cell line (HEK293) Human TMEM185A 1:3~1:6 Negative Online Inquiry
KO24807 TMEM185A Knockout cell line (A549) Human TMEM185A 1:3~1:4 Negative Online Inquiry

Background

TMEM185A Gene Knockout Cell Lines represent a pioneering advancement in biological research, specifically designed to facilitate the study of the TMEM185A gene's functions and associated pathways. These cell lines are meticulously developed by utilizing CRISPR-Cas9 technology, allowing for the precise deletion of the TMEM185A gene, which plays a pivotal role in various cellular processes, including regulation of membrane trafficking and cellular stress responses. By providing a robust model for gene function studies, these knockout lines enable researchers to investigate the implications of TMEM185A in cellular homeostasis and its potential involvement in disease mechanisms.

The key functionality of TMEM185A Gene Knockout Cell Lines lies in their ability to mimic pathological conditions by omitting the target gene, thereby providing insights into the biological consequences of its absence. This model allows scientists to analyze alterations in cell signaling pathways, differences in cellular metabolism, and changes in gene expression profiles related to TMEM185A deficiency. Such detailed examination is invaluable for elucidating the gene's role in diseases such as cancer, neurodegeneration, and other disorders.

Scientifically, the applications of these knockout cell lines extend far beyond basic research; they are instrumental in drug discovery, biomarker identification, and therapeutic development, providing a necessary tool for translational studies. Compared to existing alternatives, TMEM185A Gene Knockout Cell Lines offer unmatched specificity and reliability in modeling gene function. Their generation using the precision of CRISPR technology ensures consistent results, reducing variability that often complicates studies based on other gene editing methods.

Researchers and clinicians will find significant value in these cell lines, as they not only provide clarity in understanding complex gene interactions but also facilitate the development of targeted therapies. Further, integrative studies utilizing these knockout models can lead to significant breakthroughs in personalizing medicine strategies.

With a commitment to innovation and precision in genetic engineering, our company specializes in providing high-quality biological products that empower researchers and clinicians in their quest to unravel the complexities of life sciences. By choosing TMEM185A Gene Knockout Cell Lines, you invest in a reliable tool that enhances research capabilities and drives scientific progress.

Please note that all services are for research use only. Not intended for any clinical use.

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