Gene: TMEM126B
Official Full Name: transmembrane protein 126Bprovided by HGNC
Gene Summary: This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20118 | TMEM126B Knockout cell line (HeLa) | Human | TMEM126B | 1:3~1:6 | Negative | Online Inquiry |
KO20119 | TMEM126B Knockout cell line (HCT 116) | Human | TMEM126B | 1:2~1:4 | Negative | Online Inquiry |
KO20120 | TMEM126B Knockout cell line (HEK293) | Human | TMEM126B | 1:3~1:6 | Negative | Online Inquiry |
KO20121 | TMEM126B Knockout cell line (A549) | Human | TMEM126B | 1:3~1:4 | Negative | Online Inquiry |
TMEM126B Gene Knockout Cell Lines are specifically engineered cellular models designed to study the function of the TMEM126B gene, which encodes a transmembrane protein associated with cellular processes like mitochondrial dynamics and signaling. These knockout cell lines serve as crucial tools for investigating gene function, elucidating molecular pathways, and developing therapeutic strategies for diseases linked to mitochondrial dysfunction.
The primary mechanism of the TMEM126B knockout involves the targeted deletion of the gene using CRISPR/Cas9 technology. This precise gene-editing approach allows researchers to observe the phenotypic and functional consequences of gene loss, providing essential insights into the role of TMEM126B in cellular metabolism, apoptosis, and oxidative stress response. By utilizing these cell lines, scientists can explore both the basic biological functions of TMEM126B and its implications in pathological conditions such as neurodegenerative diseases and cancer.
In research and clinical settings, the scientific importance of TMEM126B Gene Knockout Cell Lines is profound. They enable researchers to dissect the pathways influenced by mitochondrial proteins, paving the way for novel therapeutic targets. Moreover, these cell lines can serve as platforms for drug screening and development, accelerating the pipeline for potential interventions.
What sets the TMEM126B Gene Knockout Cell Lines apart from alternative products is their rigorous validation and characterization, ensuring reliable and reproducible results. With a focus on quality and user-friendliness, these cell lines are optimized for various applications, including gene expression studies, protein interaction assays, and metabolic profiling.
For researchers and clinicians invested in mitochondrial biology and signaling pathways, the TMEM126B Gene Knockout Cell Lines offer unparalleled value. They empower users to advance their understanding of critical cellular functions while facilitating innovative research directions. Our company is dedicated to providing high-quality biological tools that enhance research capabilities, backed by extensive expertise in genetic engineering and cell line development.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.