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TMEM123 Knockout Cell Lines

Gene: TMEM123

Official Full Name: transmembrane protein 123provided by HGNC

Gene Summary: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30684 TMEM123 Knockout cell line (HeLa) Human TMEM123 1:3~1:6 Negative Online Inquiry
KO30685 TMEM123 Knockout cell line (HCT 116) Human TMEM123 1:2~1:4 Negative Online Inquiry
KO30686 TMEM123 Knockout cell line (HEK293) Human TMEM123 1:3~1:6 Negative Online Inquiry
KO30687 TMEM123 Knockout cell line (A549) Human TMEM123 1:3~1:4 Negative Online Inquiry

Background

TMEM123 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular biology and genetics, designed to facilitate the in-depth study of gene function and its implications in various biological processes. These cell lines have been specifically engineered to lack the TMEM123 gene, enabling researchers to investigate the gene's role in cellular functions such as metabolism, signaling pathways, and disease pathology.

The primary mechanism of action for these knockout cell lines involves the targeted disruption of the TMEM123 gene, achieved through advanced genome editing techniques such as CRISPR-Cas9. This approach ensures precise alterations to the genetic material, thereby allowing for a clearer understanding of gene functionality and its impact on cell behavior. Researchers utilizing these cell lines can effectively elucidate the biological pathways influenced by TMEM123, leading to insights relevant to cancer research, neurobiology, and regenerative medicine.

From a scientific standpoint, TMEM123 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They provide a unique platform for the development of therapeutic strategies aimed at diseases where TMEM123 is implicated. Furthermore, they can serve in high-throughput screening assays to identify potential drug candidates that may modulate the effects of TMEM123, making them a critical asset in pharmaceutical development.

One of the distinct advantages of choosing TMEM123 Gene Knockout Cell Lines is their robustness and reliability compared to traditional knockout models. The well-characterized nature of these lines minimizes variability and accelerates experimental timelines, allowing researchers to obtain reproducible results. Additionally, our optimal culture conditions and detailed protocols enhance user experience, making it easier for researchers to integrate these cell lines into their existing workflows.

The value of TMEM123 Gene Knockout Cell Lines extends beyond mere genetic manipulation; they represent a powerful resource for driving innovation and discovery in gene function research. By leveraging our product, researchers and clinicians can harness the potential of precise genome editing to make significant advancements in their respective fields.

At [Your Company Name], we pride ourselves on our commitment to excellence in biotechnology and our expertise in developing high-quality biological tools. Our TMEM123 Gene Knockout Cell Lines are a testament to our focus on enhancing research productivity and supporting the scientific community's quest for knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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