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TMEM102 Knockout Cell Lines

Gene: TMEM102

Official Full Name: transmembrane protein 102provided by HGNC

Gene Summary: Involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; response to cytokine; and signal transduction. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in cell surface. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13271 TMEM102 Knockout cell line (HeLa) Human TMEM102 1:3~1:6 Negative Online Inquiry
KO13272 TMEM102 Knockout cell line (HCT 116) Human TMEM102 1:2~1:4 Negative Online Inquiry
KO13273 TMEM102 Knockout cell line (HEK293) Human TMEM102 1:3~1:6 Negative Online Inquiry
KO13274 TMEM102 Knockout cell line (A549) Human TMEM102 1:3~1:4 Negative Online Inquiry

Background

TMEM102 Gene Knockout Cell Lines are uniquely engineered cellular models that allow for the targeted disruption of the TMEM102 gene, known for its involvement in various cellular processes, including cell signaling and membrane dynamics. This product provides researchers with a critical tool to study the functional roles of TMEM102 in normal physiology and disease states, particularly in the context of neurodegenerative diseases where its dysregulation may contribute to pathogenesis.

The primary mechanism of action with TMEM102 Gene Knockout Cell Lines involves the precise elimination of the target gene through CRISPR/Cas9 technology. This approach creates mutations that prevent the synthesis of functional TMEM102 protein, thereby enabling the investigation of its physiological roles through comparative studies with unmodified control cell lines. By utilizing these knockout models, researchers can elucidate the gene's function, assess downstream signaling pathways, and identify potential therapeutic targets.

The scientific importance of this product extends into both basic and applied research settings. In oncology, neuroscience, and general cell biology, these knockout cell lines facilitate the in-depth exploration of TMEM102’s role, paving the way for the development of targeted therapies. Furthermore, they can run parallel with existing biological assays to evaluate effects on cellular viability, proliferation, and response to pharmacological agents.

One of the distinctive advantages of using TMEM102 Gene Knockout Cell Lines is the efficiency and specificity of the CRISPR-based approach, which surpasses traditional gene knockdown methods that typically yield partial reduction of target gene expression. This specificity reduces the potential for off-target effects and provides clearer insights into gene function. Additionally, these cell lines are readily available for academic and pharmaceutical research, streamlining experimental workflows.

For researchers and clinicians, this knockout product is invaluable as it accelerates the discovery of molecular mechanisms underlying diseases, thereby supporting the development of innovative therapeutic strategies. The ability to manipulate TMEM102 functions in a controlled manner aligns with the growing demand for precision medicine approaches.

Our company, with its expertise in genetic engineering and cellular biology, strives to provide high-quality, reliable biological products that meet the rigorous demands of contemporary research. The TMEM102 Gene Knockout Cell Lines exemplify our commitment to advancing science and supporting the research community with cutting-edge resources.

Please note that all services are for research use only. Not intended for any clinical use.

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