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TMC5 Knockout Cell Lines

Gene: TMC5

Official Full Name: transmembrane channel like 5provided by HGNC

Gene Summary: Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13362 TMC5 Knockout cell line (HeLa) Human TMC5 1:3~1:6 Negative Online Inquiry
KO13363 TMC5 Knockout cell line (HCT 116) Human TMC5 1:2~1:4 Negative Online Inquiry
KO13364 TMC5 Knockout cell line (A549) Human TMC5 1:3~1:4 Negative Online Inquiry

Background

TMC5 Gene Knockout Cell Lines are genetically modified cell lines in which the TMC5 gene has been deliberately disrupted using advanced gene-editing technologies, such as CRISPR-Cas9. This specific alteration facilitates the investigation of the TMC5 gene's function and its potential roles in various biological processes, including cellular signaling, immune response, and disease progression. By knocking out the TMC5 gene, researchers can create models that mimetically reflect key physiological or pathological traits, allowing for a deeper understanding of its contributions to cellular behavior.

The key mechanism behind TMC5 Gene Knockout Cell Lines lies in the precise gene editing accomplished through non-homologous end joining (NHEJ), which results in frameshift mutations and loss of gene function. This permits researchers to directly assess the effects of TMC5 depletion on cellular pathways and responses, facilitating insights into disease mechanisms or therapeutic targets. The unique ability to create homogenous populations with a complete knockout of TMC5 enables reproducible experiments that are crucial for validation in both basic and applied research settings.

The scientific importance of TMC5 Gene Knockout Cell Lines extends to their applications in drug discovery, target validation, and the study of genetic disorders. They serve as valuable tools for understanding the implications of TMC5 in pathophysiological contexts, enabling the exploration of novel therapies and improving clinical strategies. Given their relevance in uncovering mechanisms underlying diseases, including cancer and genetic disorders, these cell lines are indispensable in both academic and pharmaceutical research settings.

What sets TMC5 Gene Knockout Cell Lines apart from traditional knockout models is their high efficiency and reliability, easing the experimental workflow for researchers. Additionally, our cell lines undergo rigorous quality control and validation, ensuring reproducibility and specificity in downstream applications.

At our company, we pride ourselves on our expertise in gene-editing technologies and our commitment to providing high-quality biological products. Our ongoing dedication to research and development ensures that we remain at the forefront of innovative solutions, helping scientists and clinicians accelerate their discoveries and improve therapeutic outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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