Gene: TM2D1
Official Full Name: TM2 domain containing 1provided by HGNC
Gene Summary: The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25293 | TM2D1 Knockout cell line (HeLa) | Human | TM2D1 | 1:3~1:6 | Negative | Online Inquiry |
KO25294 | TM2D1 Knockout cell line (HCT 116) | Human | TM2D1 | 1:2~1:4 | Negative | Online Inquiry |
KO25295 | TM2D1 Knockout cell line (HEK293) | Human | TM2D1 | 1:3~1:6 | Negative | Online Inquiry |
KO25296 | TM2D1 Knockout cell line (A549) | Human | TM2D1 | 1:3~1:4 | Negative | Online Inquiry |
TM2D1 Gene Knockout Cell Lines represent a cutting-edge biological tool designed for sophisticated studies in gene function and therapeutic development. These cell lines are specifically engineered to exhibit a complete absence of the TM2D1 gene, facilitating the investigation of its biological role in various cellular processes such as signaling pathways, proliferation, and apoptosis.
The key function of the TM2D1 knockout cell lines lies in their ability to serve as a robust model for deciphering the consequences of TM2D1 gene disruption. By utilizing CRISPR-Cas9 technology or other gene-editing modalities, researchers can accurately observe altered cellular behaviors and assess resultant phenotypic changes. This mechanism of targeted gene inactivation allows scientists not only to delineate the gene's specific functions but also to explore its implications in disease states, particularly in cancer research and metabolic disorders.
The scientific importance of TM2D1 knockout cell lines extends into both research and clinical settings, serving as invaluable resources for drug discovery, biomarker identification, and the development of gene therapies. By investigating pathways influenced by TM2D1, researchers can unveil novel therapeutic targets that may lead to more effective treatments.
Compared to traditional cell lines or models that contain the TM2D1 gene, these specialized knockout variants afford unique insights by eliminating confounding variables attributed to gene expression. Additionally, their availability can significantly streamline experimental workflows, enhancing reproducibility and easing data interpretation.
For researchers, clinicians, and biopharmaceutical companies, the value of TM2D1 Gene Knockout Cell Lines is undeniable. They empower users to conduct rigorous investigations into gene function, paving the way for groundbreaking discoveries in molecular biology and medicine.
Our company, with extensive expertise in genetic engineering and cell line development, is committed to providing high-quality biological products that drive innovation in life sciences. We understand the nuances of research needs, and our TM2D1 knockout cell lines exemplify our commitment to excellence and precision in advancing scientific knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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