Gene: TLR2
Official Full Name: toll like receptor 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00103 | TLR2 Knockout cell line (HEK293) | Human | TLR2 | 1:3~1:6 | Negative | Online Inquiry |
KO00761 | TLR2 Knockout cell line (A549) | Human | TLR2 | 1:3~1:4 | Negative | Online Inquiry |
KO00874 | TLR2 Knockout cell line(THP-1) | Human | TLR2 | 1:2-1:4 | Negative | Online Inquiry |
TLR2 Gene Knockout Cell Lines are meticulously engineered cellular models designed to investigate the functional roles of the Toll-like receptor 2 (TLR2) in various biological pathways, particularly in innate immunity. TLR2 is a key player in recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. By utilizing these knockout cell lines, researchers can elucidate the mechanisms through which TLR2 mediates cellular signaling, responses to bacterial infections, and its interaction with other immune receptors.
The primary function of TLR2 knockout cell lines lies in their ability to facilitate investigations into TLR2-dependent signaling pathways. By comparing these knockout lines with wild-type controls, scientists can assess the impact of TLR2 deficiency on cytokine production, cell proliferation, and immune cell activation. This is particularly important for studying chronic inflammatory conditions, autoimmune diseases, and potential therapeutic interventions that target TLR2.
In research and clinical settings, TLR2 knockout cell lines play a crucial role in drug development and vaccine research, providing valuable insights into immune responses and pathogen recognition. Their use is pivotal in identifying potential therapeutic targets for modulating the immune response against infectious diseases and inflammatory disorders.
What sets our TLR2 Gene Knockout Cell Lines apart is their high-quality genetic modification and validation, which ensure reproducibility and reliability in experimental results. Compared to traditional models, these knockout cell lines enable a more precise understanding of TLR2’s contribution to immune processes, thus paving the way for innovative research.
For researchers and clinicians eager to explore immune regulation and pathogen response, our TLR2 Gene Knockout Cell Lines offer an unrivaled tool to dissect complex biological interactions. Our company prides itself on delivering advanced biological research products backed by rigorous scientific expertise and unparalleled support, ensuring the success of your studies.
Please note that all services are for research use only. Not intended for any clinical use.
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