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TLN2 Knockout Cell Lines

Gene: TLN2

Official Full Name: talin 2provided by HGNC

Gene Summary: This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08716 TLN2 Knockout cell line (HeLa) Human TLN2 1:3~1:6 Negative Online Inquiry
KO08717 TLN2 Knockout cell line (HCT 116) Human TLN2 1:2~1:4 Negative Online Inquiry
KO08718 TLN2 Knockout cell line (HEK293) Human TLN2 1:3~1:6 Negative Online Inquiry
KO08719 TLN2 Knockout cell line (A549) Human TLN2 1:3~1:4 Negative Online Inquiry

Background

TLN2 Gene Knockout Cell Lines are specialized cellular models where the TLN2 gene has been specifically inactivated or “knocked out” through targeted genome editing techniques, such as CRISPR-Cas9. TLN2 (talin-2), a critical component of the cytoskeleton, is involved in integrin-mediated signaling pathways and is essential for cellular adhesion, migration, and focal adhesion dynamics. By disrupting the function of this gene, these cell lines provide researchers with an invaluable tool to investigate the roles and implications of TLN2 in various physiological and pathological contexts.

The key function of TLN2 Gene Knockout Cell Lines lies in their ability to illuminate the molecular mechanisms by which TLN2 influences cellular processes. Researchers can explore how the absence of TLN2 affects cell morphology, migration rates, and intracellular signaling cascades, shedding light on the gene's role in cancer progression, wound healing, and neurodegenerative diseases. This product enables precise studies of TLN2’s contributions to cell behavior, providing a solid foundation for both basic research and therapeutic investigations.

The scientific importance of these cell lines extends into various research and clinical settings. For instance, they can be utilized to develop novel cancer therapies that exploit the altered integrin signaling pathways due to TLN2 deficiency. Additionally, using these knockout lines facilitates the identification of compensatory mechanisms that might emerge in response to gene inactivation, thereby enhancing our understanding of redundancy in biological systems.

Compared to traditional knockout models, TLN2 Gene Knockout Cell Lines offer improved specificity and efficiency, resulting from contemporary gene editing methodologies. They are readily available for various cell types—enabling flexibility across diverse experimental environments—and come with validated knockdown efficiency, ensuring robust experimental outcomes.

Researchers, clinicians, and pharmaceutical developers will find value in adopting TLN2 Gene Knockout Cell Lines as they represent cutting-edge technology capable of answering pivotal biological questions. The insights derived from experiments using these cell lines can expedite the development of targeted therapies and diagnostic tools.

Our company has extensive expertise in developing advanced biological research products, ensuring that TLN2 Gene Knockout Cell Lines meet rigorous quality standards and provide reliable results for the scientific community. We are committed to empowering researchers with the tools necessary to make significant discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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